cefepime


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Related to cefepime: Cefixime

cefepime

 [sef´ĕpēm]
a semisynthetic fourth-generation cephalosporinantibiotic; used in the treatment of infections of the skin and soft tissues and of the respiratory and urinary tracts. Administered intravenously or intramuscularly as the hydrochloride salt.

cefepime

/cef·e·pime/ (sef´ĕpēm) a fourth-generation cephalosporin antibiotic; used as the hydrochloride salt.

cefepime

(sĕf′ə-pēm′)
n.
A broad-spectrum cephalosporin antibiotic, C19H24N6O5S2, used in its hydrochloride form to treat a variety of infections, including skin and urinary tract infections and certain types of pneumonia.

cefepime

a fourth-generation cephalosporin.
indications It is used to treat infections caused by gram-negative bacilli, including Escherichia coli, Proteus, and Klebsiella; gram-positive organisms, including Streptococcus pneumoniae, S. pyogenes, and Staphylococcus aureus; and infections of the lower respiratory tract, urinary tract, skin, and bone.
contraindications Known hypersensitivity to cephalosporins prohibits its use. It also should not be used in infants less than one month old.
adverse effects Life-threatening effects include nephrotoxicity, renal failure, leukopenia, thrombocytopenia, agranulocytosis, neutropenia, lymphocytosis, eosinophilia, pancytopenia, hemolytic anemia (rare), and anaphylaxis. Other serious effects include GI bleeding; increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, lactic dehydrogenase, and alkaline phosphatase; proteinuria, candidiasis, increased blood urea nitrogen, and thrombophlebitis. Common side effects include nausea, vomiting, diarrhea, and anorexia.

cefepime

Maxipime® Infectious disease A 4th-generation cephalosporin Indications RTIs–eg bronchitis, pneumonia; cellulitis and other skin and soft-tissue infections; UTIs–eg pyelonephritis, febrile neutropenia, PID, gonorrhea, septicemia, intra-abdominal infections, meningitis, surgical prophylaxis. See Cephalosporin.

cefepime (sef´əpēm),

n brand name: Maxipime;
drug class: fourth-generation cephalosporin;
action: inhibits cell wall synthesis in sensitive organisms and is bactericidal;
uses: respiratory tract, urinary tract, and skin and other soft tissue infections associated with gram-negative organisms.

cefepime

a fourth generation cephalosporin antibiotic.
References in periodicals archive ?
Cefepime versus ceftazidime: considerations for empirical use in critically ill patients.
The panel of antimicrobial drug disks (Becton Dickinson, Sparks Glencoe, MD, USA) used contained ampicillin, amoxicillin/clavulanic acid, ceftazidime, cefalothin, ciprofloxacin, cefpodoxime, cefotaxime, cefuroxime, cefepime, cefoxitin, gentamicin, and tetracycline.
The launch of Cefepime further bolsters our leadership position as a provider of the broadest portfolio of generic anti-infective injectable products," said Tom Silberg, President of APP.
AmpC producers are susceptible to fourth generation cephalosporins like cefepime while ESBL producers are variably resistant to fourth-generation cephalosporins (15).
It has been reported that the use of cefepime increases the sensitivity of DDST with extended spectrum cephalosporins for the detection of ESBLs in K.
In DDST cefepime and cefotaxime together with the clavulanate containing disk detected most of the ESBL producing isolates.
Tenders are invited for Supply of Tab Amoxicillin, Tab Azithromycin, Tab Cefpodoxime, Tab Cefuroxime, Tab Levofloxacin, Cap Cephalexin, Inj Amikacin, inj Cefepime, Inj Cefotaxim, Inj Ceftriaxone, Syp Dry Cephalexin, Inj Water for Injection IP.
Antimicrobial drug MICs for Acinetobacter genomospecies 15TU isolates from cows and reference strains, France, August 2010 * MIC, [micro]g/mL Acinetobacter genomospecies 15TU Drug class BY1 BY2-BY9 Penicillins and combinations Amoxicillin >256 128-256 Amoxicillin + CLA >256 128-256 Cephalosporins Cefoxitin 32 16-32 Cefotaxime 32 16-32 Ceftazidime 32 16-32 Cefepime 16 4-16 Monobactam (aztreonam) 64 32 Carbapenems Meropenem 16 2-4 Imipenem >32 4-6 Doripenem 8 2-4 Cyclines Tetracycline >256 >256 Tigecycline 0.
They reviewed the charts of patients receiving the antibiotics to look for inappropriate use of vancomycin and cefepime.
Maxipime is contraindicated for patients who have shown hypersensitivity reactions to cefepime or the cephalosporin class of antibiotics, penicillins or other beta-lactam antibiotics.
pneumoniae (N = 471) (N = 636) Antibiotic N Overall Range N Overall Range Ampicillin 396 84 78-90 623 98 88-100 Cefuroxime 52 11 5-37 330 52 31-62 Ceftriaxone/ 47 10 3-14 293 46 13-61 cefotaxime Cefepime 28 6 0-11 280 44 12-59 Co-amoxiclav 78 37 15-52 330 52 22-61 Piperacillin- 52 11 4-18 254 40 26-53 tazobactam Ciprofloxacin 95 20 12-26 197 31 0-49 Levofloxacin 90 19 9-31 203 32 0-49 Ertapenem 0 0 -- 12 2 0-10 Imipenem 0 0 -- 0 0 -- Meropenem 0 0 -- 0 0 -- Enterobacter spp.
Results of disk-diffusion susceptibility testing showed that all isolates were susceptible to cefotaxime, cefepime, piperacillin--azobactam, ertapenem, imipenem, meropenem, ciprofloxacin, gentamicin, and amikacin and that all were resistant to cefazolin.