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Related to cefaclor: cephalexin


a semisynthetic broad-spectrum second-generation cephalosporinantibiotic administered orally in treatment of otitis media and infections of the respiratory tract, urinary tract, and skin and soft tissues.


Apo-Cefaclor (CA), Distaclor (UK), PMS-Cefaclor (CA), Raniclor

Pharmacologic class: Second-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B


Interferes with bacterial cell-wall synthesis, causing cell to rupture and die


Capsules: 250 mg, 500 mg

Oral suspension: 125 mg/5 ml, 187 mg/5 ml, 250 mg/5 ml, 375 mg/5 ml

Tablets (extended-release): 500 mg

Indications and dosages

Uncomplicated skin infections caused by Staphylococcus aureus

Adults and children ages 16 and older: 375 mg P.O. (extended-release tablet) q 12 hours for 7 to 10 days

Pharyngitis and tonsillitis not caused by Haemophilus influenzae

Adults and children ages 16 and older: 375 mg P.O. (extended-release tablet) q 12 hours for 10 days

Chronic bronchitis and acute bronchitis not caused by H. influenzae

Adults and children ages 16 and older: 500 mg P.O. (extended-release tablet) q 12 hours for 7 days

Otitis media caused by staphylococci; lower respiratory tract infections caused by H. influenzae, S. pyogenes, and S. pneumoniae; pharyngitis and tonsillitis caused by S. pyogenes; urinary tract infections caused by Klebsiella species, Escherichia coli, Proteus mirabilis, and coagulase-negative staphylococci

Adults and children ages 13 to 17: 250 mg P.O. q 8 hours. For severe infections, 500 mg P.O. q 8 hours.

Children: 20 mg/kg/day P.O. in divided doses q 8 hours. For serious infections, 40 mg/kg/day P.O. in divided doses q 8 hours. Maximum dosage is 1 g/day.

Dosage adjustment

• Renal insufficiency

• Elderly patients


• Hypersensitivity to cephalosporins or penicillins


Use cautiously in:

• renal impairment, phenylketonuria

• history of GI disease (especially colitis)

• emaciated patients

• elderly patients

• pregnant or breastfeeding patients

• children.


• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.

• Be aware that cross-sensitivity to penicillins may occur.

• Give extended-release tablets with food to enhance absorption.

• Don't give antacids within 2 hours of extended-release form.

Adverse reactions

CNS: headache, lethargy, paresthesia, syncope, seizures

CV: hypotension, palpitations, chest pain, vasodilation

EENT: hearing loss

GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis

GU: vaginal candidiasis, nephrotoxicity

Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression

Hepatic: hepatic failure, hepatomegaly

Musculoskeletal: arthralgia

Respiratory: dyspnea

Skin: urticaria, maculopapular or erythematous rash

Other: chills, fever, superinfection, anaphylaxis, serum sickness


Drug-drug. Aminoglycosides, loop diuretics: increased risk of nephrotoxicity

Antacids: decreased absorption of extended-release cefaclor tablets

Chloramphenicol: antagonistic effect

Probenecid: decreased excretion and increased blood level of cefaclor

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels
Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results

Hemoglobin, platelets, white blood cells: decreased values

Patient monitoring

• Assess CBC and kidney and liver function test results.

• With long-term therapy, obtain monthly Coombs' test.

• Monitor for signs and symptoms of superinfection and other serious adverse reactions.

Patient teaching

• Instruct patient to take drug with food or milk to reduce GI upset.

• Advise patient to complete entire course of therapy even if he feels better.

• Tell patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, or difficulty breathing.

• Instruct patient to avoid taking antacids within 2 hours of extended-release cefaclor.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.


/cef·a·clor/ (sef´ah-klor) a semisynthetic, second-generation cephalosporin effective against a wide range of gram-positive and gram-negative bacteria.


A broad-spectrum cephalosporin antibiotic, C15H14ClN3O4S, that is given orally.


a cephalosporin antibiotic.
indications It is prescribed in the treatment of selected infections caused by susceptible strains of bacteria.
contraindications Known hypersensitivity to cephalosporins prohibits its use. It is used with caution in patients who are allergic to penicillin.
adverse effects Among the most serious adverse reactions are hypersensitivity reactions and diarrhea, nausea, and vomiting.


A broad-spectrum antibiotic. One of the CEPHALOSPORINS that can be taken by mouth. Brand names are Distaclor and Keftid.


a second generation cephalosporin antibiotic, administered orally. Not widely used in veterinary medicine.
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One designated API, cefaclor, showing the lowest application in volume was not accepted.
Ampicillin (AMP), Amoxycillin (AML), Ceftriaxone (CRO), Ceftiofur (EFT), Cefaclor (CEC) respectively, 35.
The three most effective antibiotics for bacterial control (nalidixic acid, cefaclor, and vancomycin) were individually added to this growth medium at concentrations of 0 (control), 512, and 1,024 mg [L.
21] Cefaclor, cefixime and loracarbef are less active in vitro against S.
Antibiotic Concentration Apramycin 15 [micro]g Streptomycin 10 [micro]g Sulphafurazole 300 [micro]g Gentamicin 10 [micro]g Trimethoprim 5 [micro]g Chloramphenicol 30 [micro]g Ampicillin 10 [micro]g Nalidixic acid 30 [micro]g Neomycin 30 [micro]g Nitrofurantoin 300 [micro]g Tobramycin 10 [micro]g Tetracycline 30 [micro]g Cefoxitin 30 [micro]g Cefaclor 30 [micro]g Table 2.
Discs with 4 broad spectrum drugs Ampicillin Group (Amoxicillin 30 g) Cephalosporin Group (Cephradine 30g Ceftrizone 30g Naldixic Acid 30g and Pipedimic Acid 30g and cefaclor 30g) Quinolone Group (Ciprofloxacin 5ug) was also used to sustain the quality of the resistance test in each batch of E.
The Company's products include Cephalexin, Cefaclor, Ethambutol, Prasugrel, Rasagiline Mesylate, Lacosamide, and Febuxostat.
has voluntarily recalled batches of Cefaclor (as monohydrate) 50 mg/mL powder for suspension (oral drops) with the brand name Ceclobid because of changes in the product's physical appearance.
25 [micro]g), Cephalexin (30 [micro]g), Cefaclor (30 [micro]g), Cefuroxime (30 [micro]g), Mecillinam (10 [micro]g) (Hi-Media, Mumbai, India).
Susceptibility to the following antimicrobial drugs was determined: penicillin, ampicillin, amoxicillin/ clavulanic acid, cefaclor, erythromycin, azithromycin, co-trimoxazole, clindamycin, fusidic acid, ofloxacin, ciprofloxacin, and levofloxacin.
cancerogenus has a natural resistance to amoxicillin, amoxicillin/clavulanic acid, cefazolin, cefaclor, cefazoline, loracarbef, and cefloxitin.