cccDNA


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cccDNA

[Abbr.of covalently closed circular DNA]
The replicative form of the DNA of the hepatitis B virus. It persists within the nuclei of infected liver cells, produces viral RNA transcripts, and is difficult to eradicate. cccDNA is thought to be the form of the virus responsible for both chronic hepatitis B infection and persistent viral infection after antiviral treatment.

cccDNA

see COVALENTLY CLOSED CIRCULAR DNA.
References in periodicals archive ?
Surrogate marker for transcriptionally active cccDNA
In preclinical animal models, Clevudine also demonstrated the ability to significantly reduce covalently closed circular DNA, or cccDNA, the form of HBV that is believed to be responsible for the persistence of an HBV infection.
In preclinical animal models, Clevudine has demonstrated the ability to significantly reduce covalently closed circular DNA, or cccDNA, which is believed to be responsible for the persistence of an HBV infection.