CccDNA | definition of cccDNA by Medical dictionary
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cccDNA [Abbr.of covalently closed circular DNA]
The replicative form of the DNA of the hepatitis B virus. It persists within the nuclei of infected liver cells, produces viral RNA transcripts, and is difficult to eradicate. cccDNA is thought to be the form of the virus responsible for both chronic hepatitis B infection and persistent viral infection after antiviral treatment.
References in periodicals archive
Acknowledgments: We thank Professor Dongping Xu (Institute of Infectious Diseases and Liver Failure Research Center of Beijing 302 Hospital of PLA, China) for technique support of cccDNA detection.
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
HBsAg level may reflect the transcriptional activity of cccDNA
as well as integrated HBV DNA mRNA production and translation to HBsAg (truncated) rather than the absolute amount of cccDNA
cccDNA is the template for viral replication in hepatocytes.
These results are not surprising because serum HBsAg is produced not only from transcriptionally active cccDNA, but also from integrated HBV DNA sequences.
Cytoplasmic viral capsids containing mature viral DNA are either transported to the nucleus, thereby replenishing cccDNA
, or bind to HBV surface antigens which have accumulated in the endoplasmic reticulum, bud through the cellular membranes and are secreted from the hepatocyte non-cytopathically, as virions.