CAV1

(redirected from caveolin-1)

CAV1

A gene on chromosome 7q31.1 that encodes caveolin 1, the main scaffolding protein of caveolae plasma membranes in most cells. Caveloin 1 links integrin subunits to the tyrosine kinase FYN, an early step in coupling integrins to the Ras-ERK pathway which drives cell cycle progression; CAV1 is a tumour suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and form a stable hetero-oligomeric complex with other colocalising proteins.

Molecular pathology
CAV1 mutations are linked to congenital generalised lipodystrphy (Berardinelli-Seip syndrome) type 3.
References in periodicals archive ?
Xuezhikang, extract of red yeast rice, improved abnormal hemorheology, suppressed caveolin-1 and increased eNOS expression in atherosclerotic rats.
This MP effect is associated not only with decreased NOS expression, but also with overexpression of caveolin-1 (21).
Accumulation of polychlorinated biphenyls in adipocytes: selective targeting to lipid droplets and role of caveolin-1.
High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients.
Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle.
The usefulness of caveolin-1 in the diagnostic setting was investigated by an immunohistochemical study (20) in which 80 epithelioid MMs and 80 lung adenocarcinomas were compared for caveolin-1 expression, with 100% sensitivity and 92.
Conjugated linoleic acid alters caveolae phospholipid fatty acid composition and decreases caveolin-1 expression in MCF-7 breast cancer cells.
For the first time, researchers from Jefferson's Kimmel Cancer Center show that loss of the tumor suppressor protein Caveolin-1 (Cav-1) induces mitochondrial oxidative stress in the stromal micro-environment, a process that fuels cancer cells in most common types of breast cancer.
It reduces lipid transport and storage by inhibiting the synthesis of FATP-4 and caveolin-1 proteins, limiting the internalization and metabolism of new fatty acids in the adipocytes.
The RLI and LD methods have been applied to study the distribution of caveolin-1 in human term placenta (Mayhew, 2009) and extended recently to study intracellular distribution of nanoparticles (Muhlfeld et al.
2:00 A REQUIREMENT OF CAVEOLIN-1 IN THE REGULATION OF TRPC1 MEDIATED [Ca.
Loss of caveolae, vascular dysfunction and pulmonary defects in caveolin-1 gene-disrupted mice.