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The 22-kD transmembrane protein associated with the membranes of caveolae and with Golgi membranes; believed to function in signal transduction, in cholesterol transport, and metabolism of the cell.
References in periodicals archive ?
Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis.
Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis.
Our study results suggest that iroxanadine promotes healing by normalizing endothelial dysfunction through the molecular chaperone amplification pathway, as well as releasing endothelial nitric oxide synthase (eNOS) from its negative regulator caveolin.
19) Caveolins are a 3member protein family with a dual and opposite role in cancer development, as they are implicated in both tumor suppression and oncogenesis.
The immunophenotype of basal-like tumors, as defined by GEP or by IHC surrogate markers, is characterized by positive expression of basal CKs, EGFR, p53, P-cadherin, caveolins 1 and 2, cyclin E, Ki-67, c-Kit, fascin, Sox2, moesin, vimentin, nestin, and laminin (Figure 2).