cathepsins


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Related to cathepsins: Cathepsin L

cathepsins

(kă-thĕp′sĭns)
A group of protein-destroying, lysosomal enzymes found in nearly every cell in the body. Many of these enzymes are released by cancer cells in excessive amounts, a factor that contributes to the invasiveness of tumors into neighboring tissues. The detection of cathepsins in tumors is strongly correlated with metastasis.
References in periodicals archive ?
The foundation of Virobay's proprietary cathepsin platform and the Virobay management team were spun-out from Celera Genomics, which was then a leader in cathepsin research.
Virobay has plans to initiate clinical studies with additional cathepsin inhibitors during 2013 as we seek to develop new therapies for underserved diseases.
Cathepsin L, a lysosomal endopeptidase, is a member of the papain-like family of cysteine proteinases (1).
Using a three-dimensional model system to study ErbB2-induced cellular invasion, the researchers demonstrated that inhibition of cathepsins prevented ErbB2-driven breast cancer invasion.
Two cathepsin K inhibitors, balicatib and odanacatib, have been tested in humans and shown to reduce markers of bone resorption and increase bone mass (24-26).
adipsin, cathepsin S, leptin, adiponectin, chemerin, plasminogen activator inhibitor 1 (PAI-1), RBP-4, serum amyloid A1 (SAA-1), tissue inhibitor of metalloproteinase 1 (TIMP-1), and thrombopoietin.
Cathepsins and compartmentalization in antigen presentation.
today announced that their development of an oral treatment for pain has reached an important milestone, as Virobay has now initiated a Phase 1 clinical trial of VBY-036 - a selective cathepsin S inhibitor.
Washington, June 2 (ANI): A research team has developed an experiment that reliably detects and quantifies mature cathepsin K - an enzyme implicated in osteoporosis, arthritis, atherosclerosis and cancer metastasis.
The reversible tight-binding inhibitors target proteases of the papain superfamily of cystein proteases, which includes several mammalian cathepsins.
It turns out that people make seven cathepsins, whereas the parasite makes only two.