ExpressGraft-C9T1 skin tissue has been genetically modified to express elevated levels of the human cathelicidin
host defense peptide.
Infections in the urinary tract induce epithelial cells to produce cathelicidin
to fight the infection.
7] The antimicrobial peptide, Cathelicidin
is directly up-regulated by 1, 25[(OH).
Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin
LL37 is the only one cathelicidin
in humans, which is proteolytically generated by proteinase 3 in neutrophils and kallikrein 5 and 7 in epidermal keratinocytes.
He and others have found upregulation of the cathelicidin
LL-37 and the pattern recognition receptor TLR-2.
The best known among these include lysozyme, cathelicidin
and defensins (5).
Amniotic fluid cathelicidin
in PPROM pregnancies: from proteomic discovery to assessing its potential in inflammatory complications diagnosis.
Gombart AF Borregaard N, Koeffler HR Human cathelicidin
antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly upregulated in myeloid cells by 1,25-dihydroxy vitamin D3.
Studies have demonstrated a role for vitamin D in the expression of the human cathelicidin
antimicrobial peptide, which plays a role in host defense against respiratory tract pathogens.
Although the exact mechanism remains poorly understood but it is though that the up regulation by vitamin D of NO, NADPH oxidase, cathelicidin
, and autophagy mechanisms in macrophages10.
Bile salts control the antimicrobial peptide cathelicidin
through nuclear receptors in the human biliary epithelium," Gastroenterol.