cathelicidin


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cathelicidin

An antimicrobial polypeptide found in the lysosomes of neutrophils and macrophages, which has sequence homology with the cathepsin family of cysteine proteinase inhibitors. Cathelicidin peptides have been isolated from many different species of mammals, and are produced in response to bacteria, viruses, fungi or vitamin D1,25.

cathelicidin

Any of a family of antibacterial, antifungal, and antiviral peptides produced by the cells of the innate immune system.
References in periodicals archive ?
In particular, they focused on the human cathelicidin antimicrobial peptide (CAMP) gene.
Drugs profiles discussed in this report includes Cathelicidin, Cell Therapy to Activate VEGF for Venous Leg Ulcers and Diabetic Foot Ulcers, CL-05, CODA-001, CureXcell, CVBT-141B, Granexin, HP-802247, LL-37, Recombinant Protein to Agonize Platelet Derived Growth Factor Receptor for Metabolic and Dermatology Diseases, RGN-137, WPP-201.
Christine Bailey agrees vitamin D is vital, pointing out a 2011 review highlighting its role in reducing the risk of bacterial and viral infections "through the production of the compound cathelicidin (a naturally occurring anti-microbial and anti-viral)".
Christine agrees vitamin D is vital, pointing out a 2011 review highlighting its role in reducing the risk of bacterial and viral infections "through the production of the compound cathelicidin (a naturally occurring anti-microbial and anti-viral)".
4) Research has shown that rosacea sufferers have an abnormally high level of cathelicidin peptides in their facial skin and that the proteolytically processed forms of cathelicidin peptides found in rosacea are different from those present in normal individuals.
Reversal of ABCG2-mediated multidrug resistance by human cathelicidin and its analogs in cancer cells.
Eczematous skin also lacks normal amounts of a natural antimicrobial agent called cathelicidin, leaving it susceptible to infections that can be hard to control.
Vitamin D regulates the production of the antimicrobial peptides cathelicidin and beta-defensin-2, which may reduce oral bacteria that contribute to gum disease," says dentist Chris Barrowman (www.
In macrophages and monocytes, antimicrobial peptide production by the vitamin D intracrine system is best demonstrated by the production of hCAP18, a cathelicidin antimicrobial peptide (CAMP) precusor that is cleaved to release LL37 (Figure 2).
Adrian Gombart and colleagues discovered that curcumin nearly tripled the expression of a gene that encodes a protein known as cathelicidin antimicrobial peptide (CAMP), which can help combat bacteria, viruses, and fungi that have not been previously encountered by the immune system.
Epithelial surfaces also contain high concentrations of broad-spectrum, cationic, antimicrobial and antiviral peptides which belong to the histatin, cathelicidin, and defensin families.
Another new finding is that the MMP pathway and the cathelicidin pathways are no longer thought to be distinct, said Dr.