catenin


Also found in: Acronyms, Encyclopedia, Wikipedia.

ca·ten·in

(ka-tēn'in),
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: β-catenin, which is linked to the cadherin itself and α-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

JUP

A gene on chromosome 17q21 that encodes a major cytoplasmic protein common to both submembranous plaques of desmosomes and intermediate junctions. JUP forms distinct complexes with cadherins, belongs to the catenin family and contains a distinct amino acid motif known as armadillo repeat.

Molecular pathology
JUP mutations are associated with Naxos disease.

ca·ten·in

(kă-tē'nin)
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: beta-catenin, which is linked to the cadherin itself, and alpha-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

catenin

a PROTEIN initially characterized because of its association with the ACTIN of the CYTOSKELETON, where it acts as a bridging protein between CADHERIN and actin.
References in periodicals archive ?
1,2) The integrity and morphology of epithelial units is maintained by E-cadherin and its undercoat proteins, the catenins ([alpha], [beta], and [gamma]]g), which are associated with the cytoplasmic domain of E-cadherin.
The epithelial cells express E-cadherin and catenins ([alpha], [beta], and [gamma]), whereas the spindle cells react to vimentin focally and to N-cadherin.
Most BSSs showed preserved expression of E-cadherin (12 of 14; 86%) and its associated catenins ([beta], 7 of 14 [50%]; [alpha]- and [gamma]-catenins, 8 of 14 [57%]) in at least one of the histologic component.
Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: correlation with disease progression and dedifferentiation.
Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromes.
4] After examination of the expression of cadherins and [Beta]-catenin, the distribution pattern of cadherin and catenin expression (plasma membrane, cytoplasm, or nucleus), intensity of staining, and percentage of cells stained were recorded.
Prognostic value of the preserved expression of E-cadherin and catenin families of adhesion molecules and of beta-catenin mutations in synovial sarcoma.