Around 5 to 10 percent of sudden cardiac deaths are arrhythmias occurring in the absence of underlying structural heart disease (long QT syndrome, Brugada syndrome, Wolff-Parkinson-White syndrome, catecholaminergic
polymorphic VT, all abnormalities seen on ECG).
A growing body of research suggests that BH4 is involved in catecholaminergic
, serotonergic, and NO systems therefore affecting monoamine synthesis.
Sympathetic and hyperthermic reactions by orexin A: Role of cerebral catecholaminergic
The company has four product candidates in development, AT132 for the treatment of X-Linked Myotubular Myopathy (XLMTM), AT342 for the treatment of Crigler-Najjar Syndrome, AT982 for the treatment of Pompe disease, and AT307 for the treatment of the CASQ2 subtype of Catecholaminergic
Polymorphic Ventricular Tachycardia (CASQ2-CPVT).
Selective loss of catecholaminergic
wake active neurons in a murine sleep apnea model.
Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic
Neuropsychological and imaging studies in children have shown that ADHD (and attentional dysfunction more broadly) is generally associated with hypofunctioning of catecholaminergic
systems within the cortico-striatal loop (Arnsten 2010; Brennan and Arnsten 2008).
polymorphic ventricular tachycardia (CPVT) is an inherited cardiac arrhythmia characterized by polymorphic ventricular tachycardia induced by adrenergic stress and has an estimated prevalence of 1 in 10000 people.
and acetylcholine esterase containing nerves of cranial and spinal dura mater in humans and rodents.
3,9-10,12] It has been suggested that some of the latter cases may be explained by cardiac channelopathies such as long QT syndrome, Brugada syndrome and catecholaminergic
polymorphic ventricular tachycardia.
This can translate to human models, in which a deficit or dysfunction of catecholaminergic
activity in the brain could lead to increased pulsatile gonadotropin-releasing hormone, luteinizing hormone (LH), prolactin, and an elevated LHrfolliclestimulating hormone ratio.
2007) Sympathetic and hyperthermic reactions by orexin A: Role of cerebral catecholaminergic