The PI has envisioned an ambitious and comprehensive project to target two severe inherited arrhythmogenic diseases: dominant catecholaminergic
polymorphic ventricular tachycardia (CPVT) and Long QT syndrome type 8 (LQT8).
In February 2014, a 17-year-old male student was admitted to a tertiary care hospital in Vancouver, British Columbia, Canada, with catecholaminergic
polymorphic ventricular tachycardia and electrical storm.
Uwe Pfeil, Justus-Liebig-University Giessen, Germany, 'Expression and physiological relevance of an intrinsic non-neuronal catecholaminergic
system in the urinary bladder'
Seemingly, reverse takotsubo, which is more common in young female patients with a mean age of 36 years, is thought to be triggered by physical or emotional stress rather than catecholaminergic
Behavioral changes and neurochemical changes to cholinergic, dopaminergic, and catecholaminergic
pathways have been reported at subacute and subchronic doses in rodent studies for select pyrethroid insecticides (Aziz et al.
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic
For example, low blood pressure associated with blood loss is relayed via sensory nerves to brainstem neurons in the A2 catecholaminergic
cell group (Palkovits and Zaborszky 1977), which then project directly to the PVN (Cunningham and Sawchenko 1988) and rapidly elicit noradrenergic activation of CRF neurons (Plotsky et al.
It increases the release of catecholamines from presynaptic storage sites and activates both peripheral and central catecholaminergic
pathways, serving as a potent CNS stimulant (Kalix 1992).
This consequence has been attributed to increased catecholaminergic
activity or direct effect of toxin to myocardial fibres.
Cardiac channelopathies are rare, potentially lethal inherited heart conditions, including Long QT Syndrome (LQTS), Short QT Syndrome (SQTS), Brugada Syndrome (BrS) and Catecholaminergic
Polymorphic Ventricular Tachycardia (CPVT).
Inherited arrhythmogenic disorders are a group of genetically determined diseases that include: long QT syndrome, short QT syndrome, Brugada syndrome, catecholaminergic
polymorphic VT, and ARVC.
Primary electrical diseases such as long QT syndrome, Brugada syndrome, short QT syndrome and catecholaminergic
polymorphic ventricular tachycardia are inherited disorders with a strong genetic basis (5).