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catechol-o-methyl transferase
(redirected from Catechol O-methyltransferase)

   Also found in: Wikipedia 0.01 sec.
catechol-o-methyl transferase (COMT)
[kat′əkol′ōmeth′il]
an enzyme that deactivates the catecholamines dopa, dopamine, epinephrine, and norepinephrine.

catechol-o-methyl transferase (COMT),
n an enzyme that deactivates epinephrine and norepinephrine.


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Treatments Various treatments for example, medications such as levodopa, Dopamine agonists, MAO B inhibitors, Catechol O-methyltransferase (COMT) inhibitors, etc.
In an open-label pilot study of 36 marijuana-dependent individuals, 12 weeks of treatment with the catechol O-methyltransferase inhibitor entacapone significantly decreased craving for marijuana in 19 (53%) of the study participants.
In contrast, PD patients are treated with a cocktail of drugs but predominantly with dopaminergic drugs such as Levodopa and/or dopamine agonists either as a monotherapy or in combination with catechol O-methyltransferase (COMT) inhibitors or monoamine oxidase (MAO) inhibitors.
 
 
 
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