Cytochrome P450 1B1 (CYP1B1) catalyses the conversion of estrone and estradiol to potentially carcinogenic catechol estrogen 4-hydroxyestrogen (4-OH).
Catechol-O-methyltransferase (COMT) enzyme which is principally responsible for both the inactivation and detoxification of carcinogenic catechol estrogens.
The inhibition of the methylation metabolism of catechol estrogens of which this is a marker, would facilitate the development of estrogen induced hormonal cancer (Wu 2002).
2]) to form the catechol estrogen 2- or 4-hydroxyl estradiol (2-OH-[E.
Epidemiologic evidence also supports a role for oxidative metabolites, particularly for catechol estrogens such as 4-OH-[E.
Catechol estrogen (free form) has been considered as one of the most likely candidates, acting as an endogenous antioxidant (6).
Radioimmunoassay and metabolism of the catechol estrogen 2-hydroxyestradiol.
Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse by primary estrogen, catechol estrogen
, and xenoestrogen.
Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-alpha knock-out (ERKO)/Wnt-1 mice: implications for initiation of mammary tumors.
Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen.
Anti oxidant activities of estrogens against aqueous and lipophillie radicals; differences between phenol and Catechol estrogens
Estradiol is hydroxylated to form the catechol estrogens
2- or 4- hydroxyestradiol and is then subsequently methylated to form 2- or 4- methoxyestradiol.