catechol O-methyltransferase

cat·e·chol O-meth·yl·trans·fer·ase

a transferase that catalyzes the methylation of the hydroxyl group at the 3 position of the aromatic ring of catechols, including the catecholamines norepinephrine and epinephrine (thus, converting to normetanephrine and metanephrine, respectively), the methyl group coming from S-adenosyl-l-methionine. An important step in the catabolism of the catecholamines.
References in periodicals archive ?
2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
In an open-label pilot study of 36 marijuana-dependent individuals, 12 weeks of treatment with the catechol O-methyltransferase inhibitor entacapone significantly decreased craving for marijuana in 19 (53%) of the study participants.
Other medications that can be associated with psychosis include monoamine oxidase-[beta] inhibitors, dopamine agonists, and catechol O-methyltransferase inhibitors.
CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS) Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
In contrast, PD patients are treated with a cocktail of drugs but predominantly with dopaminergic drugs such as Levodopa and/or dopamine agonists either as a monotherapy or in combination with catechol O-methyltransferase (COMT) inhibitors or monoamine oxidase (MAO) inhibitors.
Ethnic differences in catechol O-methyltransferase pharmacogenetics: Frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.
CATECHOL O-METHYLTRANSFERASE (COMT) INHIBITORS Useful adjuncts to levodopa, greatly reducing "on-off" fluctuations.
Another catechol O-methyltransferase enzyme inhibitor thought to be safer is expected to reach the market soon.
Plasma circulating catechol estrogens are known to be rapidly metabolized by erythrocytic catechol O-methyltransferase to the corresponding guaiacol estrogens, such as 2-methoxyestrone or 2-methoxyestradiol (7,8).