CATAPULT

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Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumours. A phase III trial that assessed the efficacy and safety of tirapazamine plus cisplatin for treating non-small-cell lung cancer (NSCLC)
Conclusion The median survival was significantly longer and the response rate was significantly greater for patients who received tirapazamine plus cisplatin than for those who received cisplatin alone. Tirapazamine enhances the activity of cisplatin in patients with advanced NSCLC and confirms that hypoxia is an exploitable therapeutic target in human malignancies
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