cataplexy


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cataplexy

 [kat´ah-plek″se]
a condition, often associated with narcolepsy; marked by abrupt attacks of muscular weakness and hypotonia triggered by an emotional stimulus, such as mirth, anger, or fear. adj., adj cataplec´tic.

cat·a·plex·y

(kat'ă-plek'sē),
A transient attack of extreme generalized weakness, often precipitated by an emotional response, such as surprise, fear, or anger; one component of the narcolepsy quadrad.
[cata- + G. plēxis, a blow, stroke]

cataplexy

/cat·a·plexy/ (kat´ah-plek″se) a condition marked by abrupt attacks of muscular weakness and hypotonia triggered by such emotional stimuli as mirth, anger, fear, etc., often associated with narcolepsy.cataplec´tic

cataplexy

(kăt′ə-plĕk′sē)
n. pl. cataplex·ies
A sudden loss of muscle tone and strength, usually caused by an extreme emotional stimulus.

cat′a·plec′tic (-plĕk′tĭk) adj.

cataplexy

[kat′əplek′sē]
Etymology: Gk, kata + plexis, stroke
a condition characterized by sudden loss of muscle tone, usually resulting in a fall, caused by strong emotions, such as anger, fear, or surprise, often associated with narcolepsy. cataplectic, adj.
A rare—1:2,000—condition characterised by recurrent episodes of abrupt decrease/loss of muscle tone either limited to muscle groups, or generalized, leading to muscle weakness, paralysis or postural collapse; cataplexy in an awake person is pathognomonic of narcolepsy, and is triggered by emotional stimuli or stress, which may cause knee-buckling; cataplectic attacks are dangerous for machinists, house painters, construction workers
Precipitating factors Outburst of emotion, strenuous physical exercise, flashes of light. It may present as a side effect of SSRI discontinuation syndrome
Diagnosis Flat EMG potentials, loss of tendon reflexes during an attack, eye movements similar to those of REM sleep, REM sleep pattern immediately on falling asleep
Management Imipramine, protripyline, IMAOs

cataplexy

Neurology An abrupt ↓/loss of muscle tone either limited to muscle groups, or generalized, leading to muscle weakness, paralysis or postural collapse; cataplexy in an awake person is pathognomonic of narcolepsy, and is triggered by emotional stimuli or stress, which may cause knee-buckling; cataplectic attacks are dangerous for machinists, house painters, construction workers Management Imipramine, protripyline, IMAOs. See Narcolepsy.

cat·a·plex·y

(kat'ă-plek-sē)
A transient attack of extreme generalized muscular weakness, often precipitated by an emotional state such as laughing, surprise, fear, or anger.
[cata- + G. plēxis, a blow, stroke]

cataplexy

The momentary paralysis, or weakness of the limbs, that sometimes affects people surprised by a strong emotion such as, anger, fear, jealousy, happiness or hilarity.

cataplexy

a human nervous condition in which individuals suddenly collapse to the ground without loss of consciousness. It can be induced by strong emotion.

Cataplexy

A symptom of narcolepsy in which there is a sudden episode of muscle weakness triggered by emotions. The muscle weakness may cause the person's knees to buckle, or the head to drop. In severe cases, the patient may become paralyzed for a few seconds to minutes.

cataplexy

a condition, often associated with narcolepsy; marked by abrupt attacks of a loss of voluntary muscular function (flaccid paralysis), except those controlling respiration and eye movement. Observed in dogs, cats and horses, especially Shetland ponies. In dogs these have been precipitated by extreme excitement, vigorous physical or sexual activity. Usually of short duration. Most cases are idiopathic, but can be associated with lesions of the brainstem.

food-elicited cataplexy test
cataleptic dogs demonstrate repeated attacks of catalepsy when presented with several individual pieces of food.
References in periodicals archive ?
The only approved treatment for cataplexy in the United States is Xyrem (sodium oxybate), a DEA Schedule III drug.
The one issue on which the committee hedged was the drug's safety, when used in doses of 6-9 mg/day for the treatment of cataplexy.
However, drug therapy only offers incomplete relief for many people with narcolepsy since residual sleepiness or episodes of cataplexy man remain and continue to negatively impact work, socialization, or one's safety to self or others.
For example, a young narcoleptic patient without cataplexy may achieve substantial relief from his or her symptoms by maintaining a regimented schedule of sleep onset and morning wake-up, as well as prescheduled daytime naps (when feasible).
Symptoms include temporary paralysis on falling asleep or waking, trance-like behaviour or, in the most extreme cases, cataplexy - where sudden loss of muscle control is sparked by amusement, anger or excitement.
In 2005, Xyrem became the first and only medication approved by the European Medicines Agency (EMEA) for the treatment of cataplexy in adult patients with narcolepsy, and the product has since been launched for this indication in Denmark, Germany, Norway and the UK.
0 million in revenue from Xyrem, the first and only approved treatment for cataplexy associated with narcolepsy.
for the treatment of excessive daytime sleepiness and cataplexy (the sudden loss of muscle tone) in adult patients with narcolepsy.
All patients with narcolepsy suffer from excessive daytime sleepiness and an estimated 60 to 90 percent suffer from cataplexy.
The Orphan Medical management team will host the call to discuss results for the quarter along with ongoing clinical and commercial efforts as well as providing an update on prescription data for Xyrem(R) (sodium oxybate) oral solution which is the first and only approved treatment for cataplexy associated with narcolepsy.
Orphan Medical Chief Medical & Scientific Officer, said, "Together, these two trials now demonstrate that Xyrem can be proposed as first-line therapy in narcolepsy, since Xyrem data has been produced to show efficacy in treating the symptoms of EDS, cataplexy and fragmented nighttime sleep.
Cataplexy is the sudden loss of muscle control ranging from slight weakness or a drooping of the face to the complete loss of muscle tone.