cataplexy


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cataplexy

 [kat´ah-plek″se]
a condition, often associated with narcolepsy; marked by abrupt attacks of muscular weakness and hypotonia triggered by an emotional stimulus, such as mirth, anger, or fear. adj., adj cataplec´tic.

cat·a·plex·y

(kat'ă-plek'sē),
A transient attack of extreme generalized weakness, often precipitated by an emotional response, such as surprise, fear, or anger; one component of the narcolepsy quadrad.
[cata- + G. plēxis, a blow, stroke]

cataplexy

/cat·a·plexy/ (kat´ah-plek″se) a condition marked by abrupt attacks of muscular weakness and hypotonia triggered by such emotional stimuli as mirth, anger, fear, etc., often associated with narcolepsy.cataplec´tic

cataplexy

(kăt′ə-plĕk′sē)
n. pl. cataplex·ies
A sudden loss of muscle tone and strength, usually caused by an extreme emotional stimulus.

cat′a·plec′tic (-plĕk′tĭk) adj.

cataplexy

[kat′əplek′sē]
Etymology: Gk, kata + plexis, stroke
a condition characterized by sudden loss of muscle tone, usually resulting in a fall, caused by strong emotions, such as anger, fear, or surprise, often associated with narcolepsy. cataplectic, adj.
A rare—1:2,000—condition characterised by recurrent episodes of abrupt decrease/loss of muscle tone either limited to muscle groups, or generalized, leading to muscle weakness, paralysis or postural collapse; cataplexy in an awake person is pathognomonic of narcolepsy, and is triggered by emotional stimuli or stress, which may cause knee-buckling; cataplectic attacks are dangerous for machinists, house painters, construction workers
Precipitating factors Outburst of emotion, strenuous physical exercise, flashes of light. It may present as a side effect of SSRI discontinuation syndrome
Diagnosis Flat EMG potentials, loss of tendon reflexes during an attack, eye movements similar to those of REM sleep, REM sleep pattern immediately on falling asleep
Management Imipramine, protripyline, IMAOs

cataplexy

Neurology An abrupt ↓/loss of muscle tone either limited to muscle groups, or generalized, leading to muscle weakness, paralysis or postural collapse; cataplexy in an awake person is pathognomonic of narcolepsy, and is triggered by emotional stimuli or stress, which may cause knee-buckling; cataplectic attacks are dangerous for machinists, house painters, construction workers Management Imipramine, protripyline, IMAOs. See Narcolepsy.

cat·a·plex·y

(kat'ă-plek-sē)
A transient attack of extreme generalized muscular weakness, often precipitated by an emotional state such as laughing, surprise, fear, or anger.
[cata- + G. plēxis, a blow, stroke]

cataplexy

The momentary paralysis, or weakness of the limbs, that sometimes affects people surprised by a strong emotion such as, anger, fear, jealousy, happiness or hilarity.

cataplexy

a human nervous condition in which individuals suddenly collapse to the ground without loss of consciousness. It can be induced by strong emotion.

Cataplexy

A symptom of narcolepsy in which there is a sudden episode of muscle weakness triggered by emotions. The muscle weakness may cause the person's knees to buckle, or the head to drop. In severe cases, the patient may become paralyzed for a few seconds to minutes.

cataplexy

a condition, often associated with narcolepsy; marked by abrupt attacks of a loss of voluntary muscular function (flaccid paralysis), except those controlling respiration and eye movement. Observed in dogs, cats and horses, especially Shetland ponies. In dogs these have been precipitated by extreme excitement, vigorous physical or sexual activity. Usually of short duration. Most cases are idiopathic, but can be associated with lesions of the brainstem.

food-elicited cataplexy test
cataleptic dogs demonstrate repeated attacks of catalepsy when presented with several individual pieces of food.
References in periodicals archive ?
1,2,22] The muscle atonia in cataplexy and sleep paralysis is physiologically similar to the atonia occurring normally during REM sleep.
The company said FT218 is a once-nightly formulation of sodium oxybate utilising its proprietary Micropump technology that is being studied for the treatment of excessive daytime sleepiness and cataplexy in patients suffering from narcolepsy.
It was only when I was referred to a neurologist for tests a few weeks later that I was diagnosed with cataplexy.
The patient described in this case report had several of the cardinal symptoms of narcolepsy: a) uncontrollable excessive daytime drowsiness; b) cataplexy (which was more serious with emotional excitation); c) disrupted nocturnal sleep; and d) REM latency of less than 20 minutes.
Cataplexy is a neurological condition where the sufferer experiences sudden attacks of muscle weakness leading to collapse.
In 2002 sodium oxybate was approved in the United States to reduce cataplexy attacks in patients with narcolepsy, but the drug is under tightly restricted distribution from Jazz Pharmaceuticals alone--not from pharmacies.
Like many narcoleptics, she has also had to deal with the associated problem of cataplexy, when a person suffers a complete collapse triggered by sudden laughter, anger or surprise.
Kay Underwood, of Barrow upon Soar, Leicestershire, has cataplexy - a sudden weakening of the muscles brought on by strong emotions.
Jed, 49, also has muscle weakening cataplexy which causes him to collapse suddenly.
Jenck's team found no signs of cataplexy as a side effect of the drug.
Hoban suspected that his "seizures" simply represented sleepiness, or perhaps the early stages of cataplexy.