catalytic triad


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Related to catalytic triad: Oxyanion hole

catalytic triad

The enzymatically active mechanism found in serine proteases, consisting of three amino acids SER-HIS-ASP (serine, histidine, and aspartic acid).
See also: triad
References in periodicals archive ?
Maximum protection of the catalytic triad by 3 loopsAccording to the current knowledge, the active site is protected by the lid or flap over the enzyme's surface in the alpha/beta hydrolase family.
This correspondence suggests that ACR mimics the protein effects of the redox neuromodulators (inactivation) by reacting with thiolate acceptors in catalytic triads.
This pointed to the soft, highly nucleophilic thiolate states of cysteine residues in protein catalytic triads as toxicologically relevant molecular targets.