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Catabolic Disease |
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Catabolic Disease A condition characterised by rapid weight loss and loss of fat and skeletal muscle mass, which may occur in a background of either an acute, self-limited disease—e.g., injury, infection—or a chronic condition—e.g.,diabetic ketoacidosis, multisystem organ failure, AIDS, advanced cancer, chemotherapy, radiation therapy
Associated clinical events Immunosuppression, muscle weakness, predisposition to pulmonary embolism, thrombophlebitis, altered stress response Management Aggressive nutritional support in catabolic diseases may not prevent protein loss; specialised nutrition—e.g., glutamine, arginine, branched-chain amino acids, n-3 (omega-3) fatty acids, growth hormone, possibly IGF-I and EGF—may decrease protein loss, hospitalisation catabolic disease Catabolic illness Metabolic disease A condition characterized by rapid weight loss and loss of fat and skeletal muscle mass, which may occur in a background of either an acute, self-limited disease–eg, injury,
infection or a chronic condition–eg DKA, multisystem organ failure, AIDS, advanced CA, chemotherapy, RT Associated clinical events Immunosuppression, muscle weakness, predisposition to PTE, thrombophlebitis, altered stress response Management
Aggressive nutritional support in CI may not prevent protein loss; specialized nutrition–eg, glutamine, arginine, branched-chain amino acids, n-3–omega-3 fatty acids, growth hormone, possibly IGF-I and EGF, may ↓ protein loss,
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