australe contain an indolizidine alkaloid castanospermine, a trihy-droxyindolizidine alkaloid 7-Deoxy-6-epi-castanospermine and a pyrrolizidine alkaloid Australine which have been shown to inhibit several glucosidases (Orwa et al.
The dry CAS extract powder mainly contains alkaloids castanospermine (RT=10.
Docking results showed that all the three isoforms of castanospermine has been showing hydrogen bonding with catalytic residues of DPP-4.
0 Table 3 GOLD score and predicted binding affinity of Castanospermine isoforms compared to Berberin.
Effects of the anti-inflammatory compounds castanospermine
, mannose-6-phosphate and fucoidan on allograft rejection and elicited peritoneal exudates.
The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine
5 NATURE that the drugs castanospermine and 1-deoxynojirimycin (dNM) hinder HIV's ability to infect monocytes and lymphocytes in cell cultures by at least 100-fold.
In the latest research, castanospermine and dNM "completely inhibited' giant-cell formation for 6 hours after the drugs were mixed with cells, and then greatly decreased it for several days after the mixing, say the scientists.
Folks, who does similar experiments with other enzyme-blocking agents, told SCIENCE NEWS that the low toxicity of dNM and castanospermine also is important.
Inhibition of experimental metastasis by castanospermine
in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors.
Celgosivir is an oral prodrug of castanospermine
, a natural product derived from the Australian Black Bean chestnut tree, Castanospermum australe.