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Caspofungin Acetate for Injection 50 mg per vial; 70 mg per vial (2 SKUs; vials)
Other drugs include itraconazole, caspofungin acetate and voriconazole.
On day 2, caspofungin acetate was added to his empirical anti-fungal infection regimen.
Caspofungin acetate (CAS) was provided by Merck & Co.
This report describes the case of a child with relapsed acute lymphoblastic leukemia (ALL) who developed cutaneous aspergillosis and subsequent multiorgan dissemination during therapeutic induction and was treated successfully with caspofungin acetate.
Caspofungin acetate is the first of a new class of antifungal agents, the echinocandins, that have fungicide activity against a wide range of pathogens including Aspergillus, Candida, and Histoplasmosis species (13,14).
Mass balance results showed that approximately 92% of the administered radioactivity was distributed to tissues by 36 to 48 hours after a single 70-mg dose of (3H) caspofungin acetate.
3% of administered dose) of covalent binding of radiolabel in plasma following single-dose administration of (3H) caspofungin acetate, which may be due to two reactive intermediates formed during the chemical degradation of caspofungin to L-747969.
After single intravenous administration of (3H) caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine.
The overall safety of caspofungin was assessed in 631 individuals who received single or multiple doses of caspofungin acetate.