CASP6

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CASP6

A gene on chromosome 4q25 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis. Effector (also called executioner) caspases CASP3, -6 and -7 are responsible for cleaving downstream substrates.
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Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway.
In Western blot tests, after electrophoresis, the transferred PVDF membranes were incubated overnight with antibodies against Akt, phosphoAkt (Ser473), GSK-3[beta], and phospho-GSK-3[beta] (Ser9) (Cell Signaling Technology, MA, USA), B-cell lymphoma-2 (Bcl-2), Bax, or cleaved cysteine-dependent aspartate-directed proteases (caspase-3, caspase-6, or caspase-9) (Abcam, CA, USA).
Sal protects against MPTP-induced toxicity in part through the regulation of the PI3K/Akt/GSK3[beta] signaling pathway, the upregulation of Bcl-2/Bax ratio, and the inhibition of the cleavage of caspase-3, caspase-6, and caspase-9.
It also phosphorylates caspase-3 and caspase-6, thus inhibiting their proapoptotic functions in a variety of cell lines [42,50,51].
This closely related with the regulation of the PI3K/Akt/GSK3[beta] signaling pathway, the upregulation of a normal Bcl-2/Bax ratio, and the inhibition of the cleaved caspase-3, caspase-6, and caspase-9.
Cytochrome c promotes the assembly of apoptosome and caspase-9 activation, which activates caspase-3 and -7 followed by caspase-6.
This enzyme might be caspase-6 which is z-VAD-fmk sensitive, but not sensitive to z-DEVD-fmk.
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