CASP6

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CASP6

A gene on chromosome 4q25 that encodes a so-called effector caspase belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of apoptosis. Effector (also called executioner) caspases CASP3, -6 and -7 are responsible for cleaving downstream substrates.
References in periodicals archive ?
Cytochrome c promotes the assembly of apoptosome and caspase-9 activation, which activates caspase-3 and -7 followed by caspase-6.
This enzyme might be caspase-6 which is z-VAD-fmk sensitive, but not sensitive to z-DEVD-fmk.
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