CASP4

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CASP4

A gene on chromosome 11q22.2-q22.3 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development. CASP4 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is highly expressed in the lung and spleen.
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The following antibodies were used according to the manufacturer's instructions: AIF (apoptosis-inducing factor), rabbit polyclonal; Bax, rabbit polyclonal; cytochrome c, mouse monoclonal; poly(ADP-ribose) polymerase (PARP), mouse monoclonal (BD PharMingen, San Diego, CA, USA); Bcl-2, mouse monoclonal (Santa Cruz Biotechnology, Santa Cruz, CA, USA); caspase-3, rabbit polyclonal (Assay Designs, Ann Arbor, MI, USA); caspase-4, caspase-8 and caspase-9, mouse monoclonal (Medical & Biological Laboratories, Nagoya, Japan); Smac/DIABLO, mouse monoclonal (BD Transduction Laboratories); [beta]-actin, mouse monoclonal (Sigma, Saint Louis, MO, USA).

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