CASP2

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CASP2

A gene on chromosome 7q34-q35 that encodes a member of the cysteine-aspartic acid protease (caspase) family of proteins, which mediate apoptosis by proteolysis of specific protein substrates. CASP2 is involved in stress-induced cell death, cell cycle maintenance and tumour suppression.

Molecular pathology
CASP2 is upregulated in neurodegenerative disorders—e.g., Alzheimer's disease, Huntington's disease and temporal lobe epilepsy.
References in periodicals archive ?
A new study reveals that the cutting of tau by an enzyme called caspase-2 may play a critical role in the disordered brain circuit function that occurs in these diseases.
In mice genetically engineered to mimic aspects of human tauopathy disorders, the researchers restored some of the learning and memory deficits by blocking caspase-2 activity, which suggests that some of the cognitive loss seen in tauopathies might be reversible.
Caspase2 has been reported as an initiator caspase, its role is very special in apoptosis since caspase-2 gene produces several alternative splicing isoforms (Bouchier-Hayes and Green, 2012).
The expression of AIF or caspase-2 was efficiently lowered using predesigned target-specific siRNA purchased from Qiagen Science.
Washington, June 26 ( ANI ): Researchers at Columbia University Medical Center (CUMC) have confirmed that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease.
Other researchers have shown that caspase-2 also contributes to the maintenance of normal synaptic functions.
This invention provides a method of inducing apoptosis, a method of determining physiological effects, a method for identifying an apoptosis inducing or inhibiting compound, a method for screening cDNA libraries of said polypeptide, a method to induce caspase-2 and caspase-3 activity to cleave poly (ADP-ribose) polymerase and fragment nuclear DNA in a cell, a method to inhibit NF-?
Now, scientists have tools that are 100- to 1,000-fold more sensitive than existing assays for caspase-2 and -6.
The cell-permeable pan-caspase inhibitor, the caspase-3 specific inhibitor, the caspase-9 specific inhibitor, the caspase-8 specific inhibitor, and the caspase-2 specific inhibitor were purchased from (Santa Cruz Biotechnology, Inc.
The researchers, from The University of Texas Health Science Center San Antonio, found that neurons lacking a substance called caspase-2 were better able to withstand pesticide-induced damage to energy centers known as mitochondria.
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
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