CASP2

(redirected from caspase-2)

CASP2

A gene on chromosome 7q34-q35 that encodes a member of the cysteine-aspartic acid protease (caspase) family of proteins, which mediate apoptosis by proteolysis of specific protein substrates. CASP2 is involved in stress-induced cell death, cell cycle maintenance and tumour suppression.

Molecular pathology
CASP2 is upregulated in neurodegenerative disorders—e.g., Alzheimer's disease, Huntington's disease and temporal lobe epilepsy.
References in periodicals archive ?
The cell-permeable pan-caspase inhibitor, the caspase-3 specific inhibitor, the caspase-9 specific inhibitor, the caspase-8 specific inhibitor, and the caspase-2 specific inhibitor were purchased from (Santa Cruz Biotechnology, Inc.
Washington, June 26 ( ANI ): Researchers at Columbia University Medical Center (CUMC) have confirmed that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease.
Other researchers have shown that caspase-2 also contributes to the maintenance of normal synaptic functions.
Shelanski and his team hypothesized that aberrant activation of caspase-2 may cause synaptic changes in Alzheimer's disease.
This invention provides a method of inducing apoptosis, a method of determining physiological effects, a method for identifying an apoptosis inducing or inhibiting compound, a method for screening cDNA libraries of said polypeptide, a method to induce caspase-2 and caspase-3 activity to cleave poly (ADP-ribose) polymerase and fragment nuclear DNA in a cell, a method to inhibit NF-?
Now, scientists have tools that are 100- to 1,000-fold more sensitive than existing assays for caspase-2 and -6.
The researchers, from The University of Texas Health Science Center San Antonio, found that neurons lacking a substance called caspase-2 were better able to withstand pesticide-induced damage to energy centers known as mitochondria.
Caspase-2 appears to be a master switch that can trigger either cell death or survival depending on the amount of cellular damage, the team found.
This research shows, for the first time, that in the absence of caspase-2 neurons increase autophagy to survive," said study co-author Marisa Lopez-Cruzan, investigator in the cellular and structural biology department at the Health Science Center.
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Full browser ?