CASP14

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CASP14

A gene on chromosome 19p13.1 that encodes a putative non-apoptotic caspase involved in keratinocyte differentiation and cornification, regulating maturation of the epidermis by proteolytic processing of filaggrin.
References in periodicals archive ?
The protein caspase-14 is crucial in maintaining the 'stratum corneum', a layer of flattened dead cells that acts as a protective barrier for our skin, their research has shown.
The mice without caspase-14 had skin that was shiny and wrinkled from dehydration due to the loss of water via the skin and was also highly sensitive to damage from UVB radiation.
Origins have identified that persistently dry skin often lacks in the enzyme Caspase-14, so their Make A Difference Plus + Rejuvenating Serum, PS34, creates a moisture reservoir within the layers of skin to rectify this.
At 2% use levels, the BEE-laced cream increased the expression of Caspase-14 (which protects skin from UVB) and hyaluronic acid in the tissue models.
Thomas Jefferson University (Philadelphia, PA) has patented an isolated nucleic acid molecule encoding a caspase-14 polypeptide or functional fragment thereof, a vector that contains the nucleic acid molecule and a host cell that contains the vector.
Caspaline 14 is a synthetic peptide designed to target and boost the expression of caspase-14, a cysteine protease linked to skin softness and suppleness.
By boosting caspase-14, which has been linked with cornifying epithelial tissue, such as the skin, and influencing terminal keratinocyte differentiation and formation of the skin's barrier function, Caspaline 14 may help limit skin damage from UV, according to the company.
Tests showed that the product boosts keratinocyte differentiation by stimulating the expression of caspase-14 and improves intercellular connections by boosting the expression of connexin 43, a major component of gap junctions involved in cell-to-cell communication.
The enzyme, caspase-14, is said to be activated during the differentiation of keratinocytes into corneocytes, which forms the stratum corneum, the skin's protective layer.
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