caspase activated DNase

caspase activated DNase

An enzyme maintained in a quiescent state by inhibitor of caspase-activated deoxyribonuclease which, when activated, triggers extrinsic apoptotic cell death.
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The chromatin of differentiating erythroblasts is cleaved into large size fragments independent of caspase activated DNase and apoptosis inducing factor.
Another AIF, Caspase Activated DNase (CAD), released from mitochondria, translocates into the nucleus, after getting cleaved by the activated caspase-3, and leads to oligoneucleosomal cleavage of DNA into 180 bp fragments (Enari et al.
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