caspase 9


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Related to caspase 9: Caspase 3, APAF3

caspase 9

A member of the CED-3 subfamily caspase-type protease activated by Apaf-1 binding, which is responsible for the proteolytic cleavage of many key proteins in apoptosis; caspase-9 plays a central role in cell death through an array of apoptosis inducers—e.g., TNF-alpha, TRAIL, anti-CD-95, FADD, TRADD4.
References in periodicals archive ?
The influence of compound 3 on caspase 3/7, caspase 8 and caspase 9 activity in CCRF-CEM leukemia cells was detected using Caspase-Glo 3/7, Caspase-Glo 8 and Caspase-Glo 9 Assay kits (Promega, Germany).
5) and reacted with a primary polyclonal antibody, ASK-1, JNK, bcl-2, cyto c, caspase 9, caspase 3, PARP and [beta]-actin for 4h at room temperature.
Briefly, sections were blocked in diluted normal blocking serum for 20 min followed by 1 h incubation with primary rabbit polyclonal antibody ASK-1, JNK, cyto c, caspase 3, bcl-2, PARP (Cell Signaling Technology, Danvers, MA, USA), caspase 9 (Santa Cruz Biotechnology, Santa Cruz, CA, USA) and TUNEL (Roche Diagnostics, Laval, Q.
6A, we measured the activation of caspases family proteins, such as caspase 9 and caspase 3 by Western blotting.
The influence of compounds 2-4 on caspase 3/7, caspase 8 and caspase 9 activity in CCRF-CEM leukemia cells was detected using Caspase-Glo 3/7, Caspase-Glo 8 and Caspase-Glo 9 Assay kits (Promega, Germany).
8 fold increase of caspase 9 activity, respectively (Fig.
Activation of caspase 9 and 8 occurred even at low concentration of PA, but caspase 3/7 activation occurred only at high concentration treatment.
Since becatamide was a most potent inhibitor of mitochondrial membrane depolarization, the effect of this amide on caspase 9 activity in [H.

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