cascade (redirected from cascaded)

cascade /cas·cade/ (kas-kad´) a series that once initiated continues to the end, each step being triggered by the preceding one, sometimes with cumulative effect.

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coagulation cascade  the series of steps beginning with activation of the intrinsic or extrinsic pathways of coagulation, or of one of the related alternative pathways, and proceeding through the common pathway of coagulation to the formation of the fibrin clot.

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cas·cade (k-skd)

n.

A succession of actions, processes, or operations, as of a physiological process.

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cascade

a series of steps or stages (as of a physiological process) which, once initiated, continues to the final step by virtue of each step being triggered by the preceding one, sometimes with cumulative effect. For example, the coagulation cascade.

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cascade Physiology A molecular system capable of self-propagation or amplification, especially of a weak signal; once a cascade is initiated, it may continue to be amplified through positive feedback loops and pathways, until down-regulated by local mechanisms–eg, by proteolytic enzymes. See Complement cascade, Ischemic cascade, Metastatic cascade.

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CASCADE Cardiology A clinical trial–Cardiac Arrest in Seattle: Conventional vs Amiodarone Drug Evaluation–that compared conventional therapy vs amiodarone, an antiarrhythmic on M&M in survivors of refractory out-of-hospital ventricular arrhythmias. See Amiodarone, Ventricular arrhythmia. Cf BASIS.