References in periodicals archive ?
In normal epiphyseal cartilage matrix, their distribution has been demonstrated to be mutually exclusive, even though both are expressed in epiphyseal cartilage chondrocytes.
At this level, the cartilage matrix showed a spongelike appearance in paraffin sections stained with hematoxylineosin.
Glucosamine and chondroitin sulfate work synergistically together on a structural level to assist in the rebuilding of cartilage and prevent further cartilage matrix breakdown.
It is the only patented product that combines glucosamine, chondroitin sulfate and manganese, the raw materials necessary for cartilage matrix protection and synthesis.
These amino acids are elementary building blocks for the synthesis of the cartilage matrix and are crucial for the optimal function of joint cartilage.
However, prolonged intake of NSAID increases the risk of gastrointestinal side effects and renal toxicity, and may inhibit synthesis of cartilage matrix," the researchers noted in their published report.
Recent studies have shown that the ingestion or injection of products containing chondroitin sulphate, glucosamine, hyaluronic acid, and cartilage matrix can reduce inflammation in joints of humans and animals, and possibly help regenerate bone cartilage tissue.
Nicolle Packer, Executive VP Glycoproteomics, Proteome Systems, said, "The chronic inflammatory process seen in osteoarthritis results in the loss of cartilage matrix in over 80% of middle-aged individuals, causing severe musculoskeletal pain and disability.
This includes activation, protein synthesis and apoptosis in macrophage, FLS and T cells, as well as macrophage recruitment and cartilage matrix assembly and degradation.
Also, because this preformed cartilage tissue is mature and surrounded by cartilage matrix, Carticel II should significantly reduce patient rehabilitation time and enable surgeons to treat larger and more degenerative defects.