carnosinase

carnosinase

 [kahr´no-sĭ-nās]
an enzyme that hydrolyzes carnosine (amino-acyl-l-histidine) and other dipeptides containing l-histidine into their constituent amino acids.

car·nos·in·ase

(kar'nō-si-nās),
Mammalian enzyme that catalyzes the hydrolysis of carnosine, producing histidine and β-alanine; a deficiency of the serum enzyme leads to elevated carnosine levels.

carnosinase

/car·no·sin·ase/ (kahr´no-sĭ-nās″) an enzyme that hydrolyzes carnosine (amino-acyl-l-histidine) and other dipeptides containing l-histidine into their constituent amino acids.
serum carnosinase deficiency  an aminoacidopathy characterized by urinary excretion of carnosine, homocarnosine in cerebrospinal fluid, and sometimes myoclonic seizures, severe mental retardation, and spasticity.

carnosinase

EC 3.4.13.3 Xaa-His dipeptidase. This is a deleted enzyme name, which is covered by:
• EC 3.4.13.18, cytosol nonspecific dipeptidase; and
• EC 3.4.13.20, beta-Ala-His dipeptidase.

carnosinase

an enzyme that hydrolyzes carnosine (amino-acyl-l-histidine) and other dipeptides containing l-histidine into their constituent amino acids.
References in periodicals archive ?
The reason carnosine disappears so quickly is that the carnosinase enzyme quickly degrades it.
Currently, the possible relationships between cerebral damage, neurocognitive function, carnosine and homocarnosine concentrations, and serum carnosinase activity during (open) heart surgery are not well understood.
Several methods have been described to determine carnosinase activity (3, 5, 7, 8,16), based on the reaction of o-phthalaldehyde (OPA) with histidine, which is liberated from the substrate (17,18).
Release of 1 nmol of histidine (the amount present in the lowest calibrant) corresponded to a serum carnosinase activity of 5 nmol histidine x [min.
We observed that serum carnosinase activity was inversely related to sodium citrate concentration.
A new test, which compares he levels of the chemicals enolase (which brain cells release when they die) and carnosinase (production halts because of brain cell death) in the blood, may help families of stroke victims prepare for the future.
Carnosinase levels in aging brain: redox state induction and cellular stress response.
N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia.
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
A typical red meat meal may provide 250 mg of carnosine, but this is quickly degraded in the body by the carnosinase enzyme.
of hamburger meat was completely cleared from the blood of study volunteers within 5-6 hours by the carnosinase enzyme, (69) Life Extension recommends that individuals seeking its anti-aging effects supplement with at least 1,000 mg of carnosine daily to maintain optimal levels in the body.
Two novel derivatives of carnosine--(S)-trolox-L-carnosine (STC) and (R)-trolox-L-carnosine (RTC) are characterized in terms of their antioxidant and membrane-stabilizing activities as well as their resistance to serum carnosinase.