carnosinase

carnosinase

 [kahr´no-sĭ-nās]
an enzyme that hydrolyzes carnosine (amino-acyl-l-histidine) and other dipeptides containing l-histidine into their constituent amino acids.

car·nos·in·ase

(kar'nō-si-nās),
Mammalian enzyme that catalyzes the hydrolysis of carnosine, producing histidine and β-alanine; a deficiency of the serum enzyme leads to elevated carnosine levels.

carnosinase

/car·no·sin·ase/ (kahr´no-sĭ-nās″) an enzyme that hydrolyzes carnosine (amino-acyl-l-histidine) and other dipeptides containing l-histidine into their constituent amino acids.
serum carnosinase deficiency  an aminoacidopathy characterized by urinary excretion of carnosine, homocarnosine in cerebrospinal fluid, and sometimes myoclonic seizures, severe mental retardation, and spasticity.

carnosinase

EC 3.4.13.3 Xaa-His dipeptidase. This is a deleted enzyme name, which is covered by:
• EC 3.4.13.18, cytosol nonspecific dipeptidase; and
• EC 3.4.13.20, beta-Ala-His dipeptidase.

carnosinase

an enzyme that hydrolyzes carnosine (amino-acyl-l-histidine) and other dipeptides containing l-histidine into their constituent amino acids.
References in periodicals archive ?
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.
Due to individual differences in plasma carnosinase levels, there is significant variability in response to carnosine ingestion.
In addition, carnosine is not addictive; there is no danger of overdose, and it does not accumulate in the organism during longterm administration because its surplus is cleaved by the enzyme carnosinase into amino acids that are easily eliminated from the organism [13].
A administracao direta de carnosina nao aumenta os seus estoques musculares, pois ela e rapidamente hidrolisada pela enzima carnosinase, presente no plasma humano (Asatoor e colaboradores, 1970; Perry e colaboradores, 1967).
Quando alimentos contendo HCDs sao ingeridos, os dipeptideos sofrem a acao de uma enzima presente na mucosa jejunal, denominada carnosinase ou CNDP1.
Currently, the possible relationships between cerebral damage, neurocognitive function, carnosine and homocarnosine concentrations, and serum carnosinase activity during (open) heart surgery are not well understood.
A new test, which compares he levels of the chemicals enolase (which brain cells release when they die) and carnosinase (production halts because of brain cell death) in the blood, may help families of stroke victims prepare for the future.
The reason carnosine disappears so quickly is that the carnosinase enzyme quickly degrades it.
Encontrada em alguns tipos de carne, a carnosina pode ser obtida pela dieta, mas nao e absorvida em sua forma integra, ja que a enzima carnosinase presente no aparelho digestorio, rapidamente hidrolisa este dipeptideo (Hobson e colaboradores, 2012).
Sua sintese ocorre pela acao da enzima carnosina sintase a partir dos aminoacidos L-histidina e b-alanina, dos quais o ultimo parece ser o precursor limitante degradado pela enzima carnosinase (Derave e colaboradores, 2010; Harris e colaboradores, 2006).
Carnosinase levels in aging brain: redox state induction and cellular stress response.
A typical red meat meal may provide 250 mg of carnosine, but this is quickly degraded in the body by the carnosinase enzyme.