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ICU/ age, mechanical Complications; y/sex ventilation, d outcome 1/43/M 25/8 Myocarditis, cardiogenic shock; survived 2/48/M 5/4 ARDS; died 3/45/F 40/13 Oseltamivir resistance; died 4/75/M 4/3 ARDS, died 5/29/M 8/0 Pneumomediastinum; pneumopericardium, bronchiolitis obliterans; survived * ALC, absolute lymphocyte count/[micro]L; Neutro, neutropenia; ICU, intensive care unit; APML, acute promyelocytic leukemia; SCT, stem cell transplant; SD, standard dose; HD, high dose; DLBCL, diffuse large B-cell lymphoma; IV, intravenous; BCNU, carmustine.
MGI PHARMA markets Aloxi(R) (palonosetron hydrochloride) Injection and Gliadel(R) Wafer (polifeprosan 20 with carmustine implant) in the United States.
The MIT had asked the patent office to grant an SPC for Gliadel which combines two elements, polifeprosan (an excipient) and carmustine (active ingredient) although the marketing of gliadel has been authorised in Germany since August 1999.
The clinicians say Temozolomide and Carmustine Implants are the biggest breakthroughs in the treatment of brain tumours for 30 years but the medicines have not received backing from the National Institute For Health and Clinical Excellence.
In more recent years, drugs such as vincristine, cyclophosphamide, carmustine and doxorubicin also have been used.
The proprietary Gliadel wafer contains a precise amount of the chemotherapeutic drug carmustine.
The patient was started on six cycles of vincristine, carmustine, and cyclophosphamide on the first day of treatment.
The wafer contains the cancer drug carmustine and up to eight can be implanted in the cavity created when a tumour is surgically removed.
C, 300 nM) and carmustine (BCNU, 50 mM), were examined on PC-3 cells.
Subsequently, stem cells were given after the administration of carmustine and 3 months later after the administration of thiotepa.