In addition, antimalarial treatment may add to cardiotoxic
26 However, the POINT's rescue protocol is based on the assertions that 1) first responders are unable to identify unresponsive pulseless patients reliably, (27) 2) naloxone administration has no role in cardiac arrest (including those due to opioid overdose), (26) 3) ventilations may complicate bystander resuscitation, making it harder to teach, learn, execute and perform under challenging circumstances, (28) and 4) significant numbers of opioid-related deaths involve polysubstance overdose with cardiotoxic
For example, high-temperature cooking of meat leads to the formation of relatively large amounts of cardiotoxic
cholesterol oxides and advanced glycation end products, whereas less of these compounds are produced when meat is cooked at lower temperatures.
Notably, the use of such therapies as trastuzumab for HER2-positive patients not only allows patients with the greatest likelihood of response to receive the drug but also, importantly, prevents patients who are unlikely to respond from being exposed to its potential cardiotoxic
Objective: This study aimed to investigate the acute cardiotoxic
effects of high dose toluene and its damage mechanisms on heart tissue in the acute period.
The Yale COPPER team examined the association between the use of adjuvant trastuzumab and anthracycline therapy and heart failure and cardiomyopathy, the most serious cardiotoxic
complications, in 45,536 female Medicare beneficiaries with early-stage breast cancer.
Because relatively limited data on quetiapine intoxications have been published, cardiac monitoring should be considered especially if cardiotoxic
drugs have been coingested.
Levobupivacaine was used preferentially, once available, as it is considered less cardiotoxic
than the racemic form (17).
These agents are used against a wide spectrum of malignancies in pediatric oncology and have played an important role in patients' cure; but unfortunately they have cardiotoxic
effects that may happen even years after completion of treatment .
It should be kept in mind that cardiac abnormalities such as conduction disorder or cardiomyopathy because of chloroquine may cause cardiotoxic
effects not only in high doses but also in therapeutic doses.
The demonstrated clinical utility of trastuzumab has created a mandate for accurate and reliable testing of breast carcinomas to ensure that patients with HER2/neu overexpressing tumors can benefit from antibody therapy, whereas patients with nonamplified tumors can be spared the potential cardiotoxic
side effects of the drug.
Neurotoxic and cardiotoxic
effects of cocaine and ethanol.