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Related to cardiolipin: Lupus anticoagulant

car·di·o·lip·in (CL),

A 1,3-bis(phosphatidyl)glycerol found in many biomembranes with immunologic properties; used in serologic diagnosis of syphilis. When mixed with lecithin and cholesterol cardiolipin will combine with the Wassermann antibody but not with the treponema-immobilizing antibody.


/car·dio·lip·in/ (-lip´in) a phospholipid occurring primarily in mitochondrial inner membranes and in bacterial plasma membranes; used in certain tests for syphilis.


A phospholipid usually obtained from beef heart, used in combination with phosphatidylcholine and cholesterol as an antigen to diagnose syphilis.


A 1,3-bis(phosphatidyl)glycerol found in many biomembranes with immunologic properties; used in serologic diagnosis of syphilis.


A substance derived from beef heart muscle and once much used in the WASSERMAN REACTION test for SYPHILIS. Current interest is focused on immunoglobulins known as anticardiolipin antibodies.

Patient discussion about cardiolipin

Q. what is anh cardiolipin antibody

A. Cardiolipin is a protein that is very common in the body. Mostly on heart and skeletal muscles. During several illnesses, mostly autoimmune, our body creates an antibody against it that do great damage and needs to cbe controlled.

More discussions about cardiolipin
References in periodicals archive ?
Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease.
Becker, "Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes," Journal of Molecular Biology, vol.
Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia.
Cardiolipin is a phospholipid and it is the major component of mitochondrial membranes, although ethanol-induced oxidative stress provokes a loss of this lipid [152, 154-157] in conjunction with the appearance of HNE [157, 158].
Antibodies to cardiolipin and hemostasis in rheumatic patients during development of rheumatic valvular disease.
It's a complex driven by cardiolipin, which re-energizes the skin and boosts its natural ability to repair.
These tests, also referred to as phospholipid antibody tests, use various techniques, such as flocculation tests or enzyme-linked immunosorbent assays (ELISA), in order to detect antibodies that target reagin, which is a complex of cardiolipin, lecithin, and cholesterol.
A full screen for hyperviscosity conditions including plasma homocysteine levels, anti-DNA antibodies, cardiolipin antibodies, protein C and protein S, factor V Leiden and prothrombin 20210A was normal, as were the blood glucose level and a lipogram.
Mitochondrial mass determination: The preferential binding of NAO to the cardiolipin moiety in mitochondria was exploited to estimate mitochondrial mass (23,25).
Diagnosis is based on thrombotic events and repeated positive tests for antiphospholipid antibodies, such as those against the phospholipid cardiolipin or the plasma protein betaz-glycoprotein I, as well as the lupus anticoagulant.
The good news for researchers is that High Performance Thin Layer Chromatography separation and quantification of sphingomylin, PC, PI, PS, PG, PE, cardiolipin, PA, lyso PC, PI, PS, PG and PE can be achieved.