TZP-102's effects on symptom severity were evaluated by a validated patient-reported outcome (PRO) instrument, the Patient Assessment of Gastrointestinal Symptoms scale (PAGI-SYM), and the Gastroparesis Cardinal Symptom
Index (GCSI) after 8, 15, and 28 days of treatment.
a cardinal symptom
of SAHS in the absence of diuretic therapy and excessive fluid intake or overload.
1ua2] >79 min (1 SD above normal; with 75% of patients >2 SD above normal), Gastroparesis Cardinal Symptom
Index greater than or equal to 2.
The fourth cardinal symptom
of PD is postural instability, which is related to rigidity.
They list the cardinal symptom
as post-exertional neuroimmune exhaustion.
Early CT may therefore be important in ruling out CRS as the cause of facial pain in those in whom this is the cardinal symptom
The Gastroparesis Cardinal Symptom
Index (GCSI) was used to measure symptom severity.
We put in a cardinal symptom
that you cannot ignore, which is rectal bleeding.
In patients who reported complete resolution of one cardinal symptom
there was an average improvement in endoscopy scores of 12%.
To date, no patient has had resolution of either cardinal symptom
after two weeks of saline irrigations.
This interim blinded data shows that approximately 20% of all patients are achieving the primary endpoint of complete resolution of both cardinal symptoms
and another 23% of patients are achieving complete resolution of one or the other cardinal symptom
at 16 weeks.
Debilitating bone pain is the cardinal symptom
of this stage of the disease and there are currently limited choices to delay this in men.