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Studies have suggested that plant-derived cardiac glycosides regulate some cellular processes, such as proliferation and apoptosis, in a variety of cancer cells (4-7).
titrated the intensity of ACE inhibition, diuretic and cardiac glycoside usage according to either N-BNP concentrations or existing clinical acumen.
Because monarch caterpillars incorporate the heart toxins, called cardiac glycosides, that milkweeds rely on for their own defense against herbivores, eating a monarch can "really set a bird's heart jumping," he observes.
Despite the potentials of this plant for bridging the enlarging gap of protein deficiency and meeting the world's demand for high quality protein crops for livestock feed, there is no human dietary or commercial demand for the seeds due to the presence of the anti-nutritional, toxic cardiac glycosides and aglycones found in them [14, 15, 16, 17, 18, 19, 20, 21].
Oleander contains two potent cardiac glycosides or cardenolides, oleandrin and neriine, which are present in all parts of plant [6,10].
beta]-Adrenergic agonists and cardiac glycosides are two well-known cardiotonics in current inotropic therapy (Stevenson 1998; Felker and O'Connor 2001).
The phytochemical screening and quantitative estimation of the percentage crude yield of chemical constituents of the plants showed that the leaves are rich in alkaloids, flavonoids, tannin, saponins and cardiac glycosides.
For example, antihypertensive/cardiac drugs, such as calcium channel blockers, beta blockers, digitalis, and the cardiac glycosides, can cause depression yet may never be considered for this.
Tiny doses of cardiac glycosides increase the force of the heartbeat while slowing its rate, and physicians have long prescribed these drugs for patients with heart failure.
Fraction Test conducted Result Fraction 1 Tannins ++ (Yellow) Alkaloids ++ Cardiac Glycosides - Steroids + Fraction 2 Tannins - (Dark green) Alkaloids ++ Cardiac Glycosides + Steroids - Fraction 3 Tannins + + (Blue black) Alkaloids + Cardiac Glycosides - Steroids - Key: ++ = Heavy + = Trace - = Absent