cardiac conduction defect

cardiac conduction defect

any impairment of the electrical pathways and specialized muscular fibers that conduct impulses through the heart and result in atrial and ventricular contraction. Conduction defects may develop between the sinus and atrioventricular (AV) nodes, between the sinus node and the AV bundle, or within the AV bundle or the left or right bundle branches. Defective transmission of cardiac impulses may be caused by ischemia, necrosis, drugs, electrolyte disturbances, or trauma. See also heart block.
References in periodicals archive ?
Fetal bradycardias--a fetal heart rate of less than 110 beats per minute--can stem from cardiac conduction defects, autoimmune diseases such as lupus or Sjogren's syndrome, or viral infections.
So far, the network has identified genetic variants associated with dementia, cataracts, high-density lipoprotein-cholesterol, red blood cell traits, type 2 diabetes and cardiac conduction defects.
Barbeau commented, "The potential role of drug metabolites in causing drug induced cardiotoxicity is not a new concept; however, the industry has been preoccupied with parent drugs as the potential cause of cardiac conduction defects and with the potassium channel as a primary basis for proarrhythmic activity.