ampullary carcinoma

(redirected from carcinoma of the ampulla of Vater)

ampullary carcinoma

A rare GI tract tumour that arises in the last centimetre of the common bile duct, comprising 7% of all periampullary malignancies. Ampullary carcinomas arise in ampullary adenomas; they usually have a better prognosis than pancreatic carcinomas, especially if the lesion is polypoid or papillary, and a worse prognosis if node-positive. The periampullary region is anatomically complex, representing the junction of three different epithelia: duodenal, pancreatic ductal, bile ductal, as well as a combination of the latter two (the ampulla of Vater).

Location
Intra-ampullary, periampullary, mixed, invasive pancreatic carcinoma.

Pathophysiology
Distinguishing between ampullary and periampullary tumours is critical, given that each type of mucosa produces a different pattern of mucus secretion (and prognosis): in general, ampullary tumours produce sialomucins and have a 100% 5-year survival, whereas periampullary tumours secrete sulfphated mucins and a 27% 5-year survival rate. Ampullary adenocarcinomas are classified as either:
(1) pancreaticobiliary—more aggressive, like that of pancreatic adenocarcinomas, CA 19-9 +ve; or
(2) intestinal—which have a prognosis similar to their duodenal counterparts, CA 19-9 –ve.
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References in periodicals archive ?
Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater.
Large cell neuroendocrine carcinoma of the ampulla of Vater with glandular differentiation.
Large somatostatin producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease: case report and review of the literature.

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