The summaries are distributed to all subgroups, and information from all disciplines is discussed in plenary sessions prior to assigning the agents to a specific carcinogenicity
In a follow-up study in 2006 by McGill University, Toronto, researchers from the same research group failed to find significant evidence of the increased risk, but nonetheless saw differences between the two groups of tricyclic antidepressants, with the group of drugs originally suspected of carcinogenicity
numerically associated with higher breast cancer risk.
Insmed has been informed by FDA that, based on its review of the information provided to date, including the rat inhalation carcinogenicity
study results, the Agency has insufficient information to assess the risks of ARIKACE in NTM patients in the planned phase 3 clinical trial.
Whether the presence of tungsten is the key factor in the alloy's carcinogenicity
needs further research," Kalinich says.
Often being found in baked, fried or grilled foods, acrylamide is a suspected carcinogen and the UK Committee on Carcinogenicity
of Chemicals in Food, Consumer Products and the Environment states that exposure to genotoxic carcinogens should be as low as reasonably possible.
The initial findings, he said, had described "clear evidence of carcinogenicity
in male rats.
Other N-nitrosamines could expand the list of "safe amines" when further studies release them from suspicion of carcinogenicity
In vitro classification of compounds for true genotoxic and nongenotoxic carcinogenicity
, using cell lines, including human liver cellular models, can be 70-90% accurate (van Delft et al.
The second edition adds provisions for explosives, respiratory and skin sensitizers, carcinogenicity
, and aspiration hazard.
They ignore compounds to which few people are exposed and those with inconclusive carcinogenicity
All the chapters have been thoroughly updated and the contents significantly expanded, including for example new chapters on pesticides, food chemicals and pharmaceuticals, as well as sections discussing endocrine disruptors and carcinogenicity
These changes may be important contributors to the mode of BD-induced carcinogenicity