glucarpardase

(redirected from carboxypeptidase G2)

glucarpardase

A bacterial enzyme that rapidly metabolises methotrexate, which can be used to treat accidental overdose.
References in periodicals archive ?
Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2.
Rescue treatments of IT MTX overdose may include cerebrospinal fluid (CSF) exchange, ventricular washout, folinic acid rescue, and the investigational agent carboxypeptidase G2, an enzyme that rapidly hydrolyzes MTX into inactive metabolites (5-9) There are only a few reports of patients with IT MTX overdose in the literature, and the management has not been uniform.