gamma-glutamyl hydrolase

(redirected from carboxypeptidase G)

γ-glu·tam·yl hy·dro·lase

(glū'tam'il hī'drō-lās),
An enzyme that catalyzes the removal of l-glutamyl residues from pteridine oligoglutamates; used in certain antitumor treatments.

GGH

A gene on chromosome 8q12.3 that encodes gamma-glutamyl hydrolase, which progressively removes gamma-glutamyl residues from pteroyl poly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. GGH may play a key role in ensuring the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
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