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carboxypeptidase |
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carboxypeptidase /car·boxy·pep·ti·dase/ (-pep´ti-das) any exopeptidase that catalyzes the hydrolytic cleavage of the terminal or penultimate bond at the end of a peptide or polypeptide where the free carboxyl group occurs.
carboxypeptidase (kärbok´sēpep´-tidās), n an exopeptidase that stimulates the hydrolytic cleavage of the last or second to last peptide bond at the C-terminal end of a peptide or polypeptide. carboxypeptidase an exopeptidase enzyme secreted by the pancreas that acts only on the peptide linkage of a terminal amino acid containing a free carboxyl group; includes carboxypeptidases A and B. |
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For many proteins, especially hormones such as insulin, a crucial enzyme called carboxypeptidase E (CPE) marks the end of the assembly line. Pancreatic islets and acini produce insulin and carboxypeptidase. Another such gene is called fat, which encodes for carboxypeptidase E, an enzyme involved in the activation of a number of prohormones, including insulin. |
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carboxypeptidase
