Overexpression of carboxylesterase
gene associated with organophosphorous insecticide resistance in cotton aphids, Aphis gossypii (Glover).
Alternatively, the absence or the lower levels of EST isozymes available may be caused by the ability of carboxylesterase
and acetylesterase to hydrolyze the fungicide compounds (Cabrio Top[R], Orthocide 500[R], Positron Duo[R] and Folicur PM[R]) as substrates instead of their typical [alpha]- and [beta]-naphthyl substrates.
Association of carboxylesterase
B electrophoretic pattern with presence and expression of urovirulence factor determinants and antimicrobial resistance among strains of Escherichia coli that cause urosepsis.
For total carbohydrate detection, blots were treated with an Immun-Blot kit (Bio-Rad) for glycoprotein detection as described (protocol lA) by the manufacturer; chicken egg ovalbumin (Sigma) and rabbit liver carboxylesterase
(Sigma) were used as positive controls.
This phenomenon is particularly well studied in the Australian sheep blowfly Lucilia cuprina (Clarke 1997), in which diazinon resistance due to an altered carboxylesterase
encoded by Rop-1 locus was associated with a fitness cost (McKenzie et al.
Genetic or biochemical markers, such as increased carboxylesterase
activity (Ma & Steeves, 1995), may provide the first clear indications of the earliest vascular differentiation.
Because ATI-5923 is designed to undergo metabolism by human carboxylesterase
and not by CYP2C9, it shouldn't be influenced by CYP2C9 genetic variations.
with broad substrate specificity causes organophosphorus, carbamate and pyrethroid resistance in peach-potato aphids (Myzus persicae).
Polyphenol esters, such as hydroxycinnamates and diferulates, have also been hypothesized to be cleaved by human enzymes, such as carboxylesterase
, present on the brush border or intracellularly within the enterocytes .
They found that carboxylesterases
in skin hydrolyzed DnBP to MnBP in all of the species studied and that inhibition of carboxylesterase
activity retarded passage of DnBP through the skin.
Haubruge E, Amichot M, Cuany A, Berge JB, Arnaud L (2002) Purification and characterization of a carboxylesterase
involved in malathion-specific resistance from Tribolium castaneum (Coleoptera: Tenebrionidae).