For example, another type of carboxylesterase
protein breaks down the cancer chemotherapy drug CPT-II (irinotecan), which is used to treat colon cancer.
Proteins identified in these studies included albumin, ES1 carboxylesterase
, propionyl and methylcrotonyl coenzyme A carboxylase-[alpha], and pyruvate carboxylase.
It is thought that the reduced vulnerability of adults is mediated primarily by the higher levels of detoxication enzymes such as the carboxylesterases
and non-target cholinesterases.
Although we identified compounds that were previously shown to inhibit a particular enzyme class or receptor, we surprisingly discovered that triclosan, a microbiocide present in personal care products, inhibits carboxylesterases
and that dichlone, a fungicide, strongly inhibits the ryanodine receptors.
(CEs) and A-esterases (AEs) inactivate a wide variety of organophosphate pesticides, either by stoichiometric binding (CE) or via catalytic hydrolysis of the activated, neurotoxic form of the pesticide (AE).
Differences in the induction of carboxylesterase
RL4 in rat liver microsomes by various perfluorinated fatty acids, metabolically inert derivatives of fatty acids.
mRNA Updated NCBI-based annotation GenBank (a) Gene LocusLind accession LocusID (d) symbols (d) description (d) no.
Previous work with PC12 cells suggested that horse serum, although heat-inactivated, nevertheless might maintain sufficient A esterase and carboxylesterase
activity to hydrolyze chlorpyrifos oxon and thus provide protection from its adverse effects (11).
The liver microsomal arylamidase responsible for the metabolism of both CDEPA and CMEPA is also a carboxylesterase
3, while four major clusters indicated lytic transglycosylase activity, bile acid activity, short chain carboxylesterase
activity and phosphoendopyruvate carbonxykinase activity in line 7.
TBX02 utilizes an established NSC line engineered to express a modified carboxylesterase
enzyme that converts the prodrug CPT-11 (Irinotecan) to the potent chemotherapy agent SN-38, which is 1000x more toxic to cancer cells than CPT-11.
A recent study in Argentina evaluated saliva sampling as a tool for biological monitoring and suggested that salivary carboxylesterase
levels might be a sensitive, noninvasive biomarker for assessing pediatric exposure to organophosphate pesticides (Bulgaroni et al.