carboxylesterase


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carboxylesterase

 [kahr-bok″sil-es´ter-ās]
an enzyme that catalyzes the hydrolysis of the esters of carboxylic acids.

carboxylesterase

/car·box·yl·es·ter·ase/ (kahr-bok″sil-es´ter-ās) an enzyme of wide specificity that catalyzes the hydrolytic cleavage of the ester bond in a carboxylic ester to form an alcohol and a carboxylic acid, including acting on esters of vitamin A.

carboxylesterase

an enzyme that catalyzes the hydrolysis of the esters of carboxylic acids.
References in periodicals archive ?
Proteins identified in these studies included albumin, ES1 carboxylesterase, propionyl and methylcrotonyl coenzyme A carboxylase-[alpha], and pyruvate carboxylase.
It is thought that the reduced vulnerability of adults is mediated primarily by the higher levels of detoxication enzymes such as the carboxylesterases and non-target cholinesterases.
Although we identified compounds that were previously shown to inhibit a particular enzyme class or receptor, we surprisingly discovered that triclosan, a microbiocide present in personal care products, inhibits carboxylesterases and that dichlone, a fungicide, strongly inhibits the ryanodine receptors.
Carboxylesterases (CEs) and A-esterases (AEs) inactivate a wide variety of organophosphate pesticides, either by stoichiometric binding (CE) or via catalytic hydrolysis of the activated, neurotoxic form of the pesticide (AE).
Differences in the induction of carboxylesterase RL4 in rat liver microsomes by various perfluorinated fatty acids, metabolically inert derivatives of fatty acids.
29225 carboxylesterase mRNA Updated NCBI-based annotation GenBank (a) Gene LocusLind accession LocusID (d) symbols (d) description (d) no.
Previous work with PC12 cells suggested that horse serum, although heat-inactivated, nevertheless might maintain sufficient A esterase and carboxylesterase activity to hydrolyze chlorpyrifos oxon and thus provide protection from its adverse effects (11).
The liver microsomal arylamidase responsible for the metabolism of both CDEPA and CMEPA is also a carboxylesterase.
3, while four major clusters indicated lytic transglycosylase activity, bile acid activity, short chain carboxylesterase activity and phosphoendopyruvate carbonxykinase activity in line 7.
TBX02 utilizes an established NSC line engineered to express a modified carboxylesterase enzyme that converts the prodrug CPT-11 (Irinotecan) to the potent chemotherapy agent SN-38, which is 1000x more toxic to cancer cells than CPT-11.
A recent study in Argentina evaluated saliva sampling as a tool for biological monitoring and suggested that salivary carboxylesterase levels might be a sensitive, noninvasive biomarker for assessing pediatric exposure to organophosphate pesticides (Bulgaroni et al.