carboxyamidotriazole


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carboxyamidotriazole

A calcium-channel blocker with tumouristatic (antiproliferative and antimetastatic) activity, as well as anti-inflammatory and analgesic activitie. It inhibits local vascular permeability stimulated by vascular endothelial growth factor (VEGF) or histamine and reduces TNF-alpha and IL-1beta levels at the site of inflammation and in serum, which may contribute to the anti-inflammatory effect.