C terminus

(redirected from carboxy terminus)

C ter·mi·nus

the end of a peptide or protein having a free carboxyl (-COOH) group.

C terminus

The end of a polypeptide chain, which has a free (unattached) carboxyl (COOH) group.

C ter·mi·nus

(tĕr'mi-nŭs)
The end of a peptide or protein having a free carboxyl (-COOH) group.
References in periodicals archive ?
We identified 2 monoclonal antibodies that reacted with amino terminus (26A1) and carboxy terminus (48A1) of EL among 15 clones.
We generated a pair of antibodies recognizing the amino terminus (26A1) and carboxy terminus (48A1) that exhibited a highly specific reactivity with the EL protein derived from hEL-myc/CHO 53A5 cells.
Large Scale Biology Corporation (Vacaville, CA) has patented galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lysosomal enzymes in a plant expression system.
The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability.
This antibody was raised against an epitope mapping the carboxy terminus of ERK-2-encoded MAP kinase p42 of rat origin.
ERK-2 was directed against an epitope mapping at the carboxy terminus of ERK-2-encoded MAP kinase p42 of rat origin.
The amidation of the carboxy terminus has been reported to protect against carboxypeptidases (26), and exoprotease resistance was characteristic to designated "second-generation" reporter peptides (Table 1).
Another region, residues 84-94, was identified as a proteoglycan-binding domain in apoB-48, and there is evidence to suggest that this region in apoB-100 is "masked" by the carboxy terminus and hence unavailable to bind vessel wall proteoglycans (12).
Mutations in the APOB gene causing the production of a truncated molecule can cause FHBL and hypocholesterolemia, whereas defects in the carboxy terminus of the LDL-receptor-binding domain of apoB cause FDB, a form of hypercholesterolemia.
On the basis of the "ribbon and bow" model of apoB structure on LDL particles, the absence of the carboxy terminus of apoB-100 would lead to enhanced receptor binding (8).
After immunization of guinea pigs with insulin lispro and screening of sera for antibodies with increased affinity and selectivity for insulin lispro vs native human insulin, we prepared a monospecific polyclonal antiserum by a novel immunoadsorption strategy using despentapeptide insulin (DPI) (4) an analog of human insulin lacking the five terminal amino acids at the carboxy terminus of the B chain.
As expected, modifications to the carboxy terminus of the B chain produced the greatest disruptions in antigenicity.