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A molecular configuration (-CONH2) that, together with the related carboximides (iminocarbonyls) (-CONH-), is a constituent of many hypnotics, including barbiturates, hydantoins, and thiazines.
Synonym(s): aminocarbonyl
References in periodicals archive ?
Larvicidal and fungicidal activity of compounds with hydrazine carboxamide and diazenecarboxamide moieties.
Xemium is BASF s next generation carboxamide, poised to further strengthen the company s leading position in the fungicide market.
Methotrexate polyglutamates are potent inhibitors of the enzyme aminoimidazole carboxamide ribonucleotide (AICAR) transformylase, among others.
The genes they have looked at are involved in the intracellular transport (reduced folate carrier 1 or RFC1), and conversion ([gamma] glutamyl hydrolase or GGH) of methotrxate, metabolism of purine and pyrimidine (methylenetetrahydrofolate reductase or MTHFR, thymidylate synthase or TS, methionine synthase or MS, serine hydroxymethyltransferase I or SHMT 1 , aminoimidazol carboxamide ribinucleotide transformylase or ATIC, methionine synthase reductase or MTRR) and efflux of the drug (multidrug resistance protein 1 or MDR1).
Raltegravir, the only INSTI to be approved for clinical use to date, is a member of the hydroxypyrimidinone carboxamide class of inhibitors, and although structurally different from DKAs, is mechanistically similar [26].
de Akypo RLM 70 INCI: laureth-3 carboxylic acid Use levels: 3-7% Applications: cosmetics and cleaners Akypo A 15 INCI: trideceth-2 carboxamide MEA Use levels: 2-5% Applications: cosmetics Akypo N INCI: PEG-4 rapeseedamide Use levels: 2-5% Applications: cosmetics and cleaners * Larex, Inc.
Saltigo also offers considerable expertise in the synthesis of new fungicidal active ingredients from the carboxamide family, which are also known as SDHI (succinate dehydrogenase inhibitors) fungicides.
8-(3,4-Dimethoxybenzylidene)-2-amino-4-(3,4-dimethoxyphenyl)-N-(2-hydroxyphenyl)-5,6,7,8-tetrahydro-4H-chromene-3- carboxamide (14a):
It catalyses the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR), as well as, the formation of adenosine monophosphate (AMP) from adenylosuccinate in the purine nucleotide cycle (Kmoch et al.
The genes analyzed were MTHFR: Methylenetetrahydrofoate reductase; TS: Thymidylate synthase; RFC1: Reduce folatecarrier1 ;MS: Methionine synthase; SHMT1: Serine hydroxymethyltransferase1; MDR1: Multidrug resistantprotein1; GGH: [gamma] glutamyl hydrolase; ATIC: Aminoimidazol carboxamide ribonucleotide transformylase; MTRR: Methionine synthase reductase.
4) Consistent with the observation that MTXGlu is a potent inhibitor of AICAR transformylase, initial studies showed increased excretion of aminoimidazole carboxamide (AICA), a metabolite of AICAR, in urine of leukemia patients taking large doses of methotrexate.