CA.1ae.4

(redirected from carbonic anhydrase 4)

CA.1ae.4

A gene on chromosome 17q23 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. Carbonic anhydrases participate in various biological processes, including respiration, calcification, maintaining acid-base balance and bone resorption, as well as producing aqueous humour, cerebrospinal fluid, saliva and gastric acid. Carbonic anhydrase 4 is a glycosylphosphatidyl-inositol-anchored membrane isozyme, expressed on the luminal surfaces of pulmonary (and other) capillaries and proximal renal tubules; it is thought to have a role in hereditary defects in bicarbonate transport.
References in periodicals archive ?
16 Science that tasting fizz begins with the enzyme carbonic anhydrase 4.
He also specifically identified an enzyme called carbonic anhydrase 4 in the detection of the gas, reports the Independent.
A team headed by Charles Zuker, a neuroscientist at Columbia University, found that a class of taste-receptor cells in the tongue respond to carbon dioxide, the gas that gives drinks their fizz, and identified an enzyme called carbonic anhydrase 4 in CO perception.