carbonic anhydrase


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Related to carbonic anhydrase: Carbonic anhydrase inhibitors, carbonic anhydrase IX

anhydrase

 [an-hi´drās]
an enzyme that catalyzes the removal of water from a compound.
carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating transfer of carbon dioxide from tissues to blood and from blood to alveolar air.

car·bon·ic an·hy·drase

a zinc-containing enzyme that catalyzes the interconversion of CO2 with HCO3- and H+. There are at least seven human isozymes that appear predominantly in red blood cells, secretory tissues, and muscle. A deficiency of carbonic anhydrase II can result in osteopetrosis and metabolic acidosis. The inhibition of carbonic anhydrase IV and possibly carbonic anhydrase II by sulfonamides is a current therapy in the treatment of glaucoma.

carbonic anhydrase

/car·bon·ic an·hy·drase/ (an-hi´-drās) an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating the transfer of carbon dioxide from tissues to blood and from blood to alveolar air.

carbonic anhydrase

[anhī′drās]
a zinc-containing enzyme in red blood cells that assists in the hydration of carbon dioxide to carbonic acid in the red blood cell so that it can be transported from the tissue cell to the lungs. Also called carbonate dehydratase.

carbonic anhydrase

an enzyme that accelerates the reaction between carbon dioxide and water to form carbonic acid in the red blood cells.

carbonic anhydrase (kärbon´ik anhī´drās´),

n an enzyme that plays a role in transferring carbon dioxide from tissue cells to the lungs by turning carbon dioxide into carbonic acid in red blood cells. Also called
carbonate dehydratase.

carbonic anhydrase

an enzyme which catalyzes the reversible conversion of carbon dioxide to bicarbonate ions and thus facilitates the transport and elimination of carbon dioxide from tissues. The enzyme is also important in making adequate calcium available for the deposition of shells on birds' eggs.

carbonic anhydrase inhibitor diuretics
diuretics such as acetazolamide exert their effect on tubular resorption in the kidney by inhibiting carbonic anhydrase. These compounds are used preferentially for the treatment of chronic glaucoma because the formation of aqueous humor is highly dependent on carbonic anhydrase.
References in periodicals archive ?
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.
Laryngeal epithelial defenses against laryngopharyngeal reflux: Investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin.
Carbonic anhydrase catalyzes carbonate ion formation from carbon dioxide in solution in seawater and its activity has long been linked with shell formation (Wilbur & Jodrey, 1956, Freeman 1960, Medakovic & Lucu 1994, Medakovic 2000).
Lukaski shows that low dietary zinc impairs red blood cell carbonic anhydrase activity, which strains the metabolic response during exercise.
In addition, given its effects on carbonic anhydrase, metabolic acidosis may occur related to urinary bicarbonate losses.
In diabetics, the oral carbonic anhydrase inhibitors may raise blood and urine sugar levels.
Subjects were excluded if they had other psychiatric diagnoses, alcohol withdrawal symptoms, clinically significant co-morbidities, kidney disease or stones, or unstable hypertension, or were pregnant or lactating, taking a medication with an effect on alcohol consumption or a carbonic anhydrase inhibitor, were ordered to receive treatment for alcohol problems, or were receiving treatment for alcoholism 30 days prior to enrollment.
Each patient received one to three of these drugs: a sulfonylurea, a thiazide, loop diuretic, a carbonic anhydrase inhibitor, a triptan, celecoxib, amprenavir, or dapsone (a sulfone).
Small changes were observed in serum bicarbonate and chloride levels; topiramate acts as a carbonic anhydrase inhibitor.
At Chembiotech, a high-tech company based on the University of Birmingham Business Park, Dr John Kennedy and his team of seven have been working on a much lighter alternative - using a natural catalyst, an enzyme called carbonic anhydrase.
Study on lipid profile, oxidation stress and carbonic anhydrase activity in patients with essential hypertension