carbonic anhydrase


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anhydrase

 [an-hi´drās]
an enzyme that catalyzes the removal of water from a compound.
carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating transfer of carbon dioxide from tissues to blood and from blood to alveolar air.

car·bon·ic an·hy·drase

a zinc-containing enzyme that catalyzes the interconversion of CO2 with HCO3- and H+. There are at least seven human isozymes that appear predominantly in red blood cells, secretory tissues, and muscle. A deficiency of carbonic anhydrase II can result in osteopetrosis and metabolic acidosis. The inhibition of carbonic anhydrase IV and possibly carbonic anhydrase II by sulfonamides is a current therapy in the treatment of glaucoma.

carbonic anhydrase

/car·bon·ic an·hy·drase/ (an-hi´-drās) an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating the transfer of carbon dioxide from tissues to blood and from blood to alveolar air.

carbonic anhydrase

[anhī′drās]
a zinc-containing enzyme in red blood cells that assists in the hydration of carbon dioxide to carbonic acid in the red blood cell so that it can be transported from the tissue cell to the lungs. Also called carbonate dehydratase.

carbonic anhydrase

an enzyme that accelerates the reaction between carbon dioxide and water to form carbonic acid in the red blood cells.

carbonic anhydrase (kärbon´ik anhī´drās´),

n an enzyme that plays a role in transferring carbon dioxide from tissue cells to the lungs by turning carbon dioxide into carbonic acid in red blood cells. Also called
carbonate dehydratase.

carbonic anhydrase

an enzyme which catalyzes the reversible conversion of carbon dioxide to bicarbonate ions and thus facilitates the transport and elimination of carbon dioxide from tissues. The enzyme is also important in making adequate calcium available for the deposition of shells on birds' eggs.

carbonic anhydrase inhibitor diuretics
diuretics such as acetazolamide exert their effect on tubular resorption in the kidney by inhibiting carbonic anhydrase. These compounds are used preferentially for the treatment of chronic glaucoma because the formation of aqueous humor is highly dependent on carbonic anhydrase.
References in periodicals archive ?
Carbonic anhydrase induction in euryhaline crustaceans is rate-limited at the post-transcriptional level.
Case 4###72###Male###Right###Beta blocker, , alpha agonist, Carbonic anhydrase inhibitors, Prostaglandin analouge
Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibition.
When methanol was used in the mobile organic phase, the sorption of proteins such as insulin, aprotinin, cytochrome c, a-lactalbumin, ribonuclease, peroxidase, albumin, enolase, and L-glutamic dehydrogenase was affected by the sorbent, but the sorption for proteins lysozyme, myoglobin, [beta]-lactoglobulin, elastase, and carbonic anhydrase was unaffected.
This study, according to Lukaski, suggests that dampened carbonic anhydrase activity may explain these effects.
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs.
For the differential diagnosis of the 4 most common types of renal cortical neoplasms, a panel of 5 IHC markers commonly used in the present cohort were carbonic anhydrase IX (Novus Biological, Littleton, Colorado), CD117 (Dako, Carpinteria, California), [alpha]-methylacyl-coenzyme A racemase (Zeta, Sierra Madre, California), cytokeratin 7 (Dako), and CD10 (Novacastra, Newcastle upon Tyne, United Kingdom).
Using a method developed by the authors, they were able to identify active carbonic anhydrase in the narrower part of the gland and confirm that carbonic anhydrase is indeed responsible for generating the pH gradient.
The enzyme activities such as catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), myeloperoxidase (MPO), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and lactate dehydrogenase (LDH) were assayed in appropriately diluted stomach tissue homogenates.
In clinical practice, most patients begin the anti-glaucoma treatments with a single topical drug such as prostaglandin analogs, [sz]-blockers, a-agonists, and carbonic anhydrase inhibitors.