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carbidopa

   Also found in: Wikipedia 0.01 sec.
carbidopa /car·bi·do·pa/ (kahr″bĭ-do´pah) an inhibitor of decarboxylation of levodopa in extracerebral tissues, used in combination with levodopa as an antiparkinsonian agent.
car·bi·do·pa (kärb-dp)
n.
A drug that increases the availability of L-dopa to the brain and is administered with it in the treatment of Parkinson's disease

carbidopa
[kär′bidō′pə]
a dopa decarboxylase inhibitor that cannot cross the blood-brain barrier.
indication It is prescribed in combination with levodopa in the treatment of idiopathic Parkinson's disease because it inhibits the degradation of levodopa in the periphery, thereby permitting a larger percentage of orally administrated doses to enter the brain.
contraindications Glaucoma, hypertension, use of a monoamine oxidase inhibitor within the past 14 days, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the most serious adverse reactions are GI bleeding, cardiac irregularity, hemolytic anemia, tardive dyskinesia, mental depression, blurred vision, and activation of malignant melanoma.

carbidopa [kahr-bĭ-do´pah]
an inhibitor of the decarboxylation of levodopa in peripheral tissues; it does not cross the blood-brain barrier and is used in combination with levodopa to control the symptoms of parkinson's disease. In the presence of carbidopa, levodopa enters the brain in larger quantities, thus avoiding the need for excessively high doses of levodopa.


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has initiated a Phase II trial of Droxidopa, a synthetic precursor of norepinephrine, both alone and in combination with carbidopa for the treatment of Fibromyalgia.
These two agents combined in a carbidopa : levodopa ratio of 1:4 or 1:10 is known by the trade name Sinemet [R].
Carbidopa inhibits the metabolic break down of levodop in the peripheries and thus allows greater penetration of this drug to the brain.
 
 
 
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