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carbidopa |
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carbidopa /car·bi·do·pa/ (kahr″bĭ-do´pah) an inhibitor of decarboxylation of levodopa in extracerebral tissues, used in combination with levodopa as an antiparkinsonian agent.
carbidopa [kär′bidō′pə] a dopa decarboxylase inhibitor that cannot cross the blood-brain barrier. indication It is prescribed in combination with levodopa in the treatment of idiopathic Parkinson's disease because it inhibits the degradation of levodopa in the periphery, thereby permitting a larger percentage of orally administrated doses to enter the brain. contraindications Glaucoma, hypertension, use of a monoamine oxidase inhibitor within the past 14 days, or known hypersensitivity to this drug prohibits its use. adverse effects Among the most serious adverse reactions are GI bleeding, cardiac irregularity, hemolytic anemia, tardive dyskinesia, mental depression, blurred vision, and activation of malignant melanoma. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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In June 2003, Orion Pharma received the Marketing Authorization from FDA for Stalevo, a new treatment of PD, which combines levodopa and carbidopa with entacapone in one tablet. In the 1970s, the original medication was combined with a second drug, carbidopa, and called Sinemet; the combination drug remains a staple treatment. The neurologist hypothesized that the tremor was due to neurotransmitter imbalance, and her medication regimen was therefore altered to levodopa carbidopa and pergolide (Tab. |
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