carbenoxolone


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carbenoxolone

A drug used to promote healing in stomach and duodenal ulcers. A brand name is Bioplex. Formulated with magnesium trisilicate it is marketed as Pyrogastrone.
References in periodicals archive ?
This ATP release was Panx1 channel-mediated as shown by the prevention of ATP release with pharmacological inhibitors, such as carbenoxolone (CBX) or [10] Panx, and with siRNA-mediated knockdown of Panx1.
Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice.
1) The drug carbenoxolone is a pharmacological analogue of glycyrrhizin, hence it manifests the same activity as licorice.
Excessive licorice consumption and carbenoxolone (a synthetic derivative of glycyrrhizinic acid used to treat gastroesophageal reflux disease) will also suppress the ratio to <1.
Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11[beta]-hydroxysteroid dehydrogenase inhibitor carbenoxolone.
Nevertheless, a study of horizontal cell-photoreceptor feedback in mouse retina using the hemichannel blocker carbenoxolone yielded data that were consistent with a model in which hemichannels modulate cone transmitter release by effectively opening more [Ca.
11-[beta]-HSD2 is also inhibited by licorice, carbenoxolone, and other commonly used drugs, which leads to increased UFC concentrations (13).
Carbenoxolone is one of the many der ivatives of glycyrrhetinic acid, a saponin obtained from the licorice root Glycyrrhizia glabra, that has been shown to be a potent inhibitor of gap-junctional communication in various cell types (11).
Among the 11[beta]-HSD 1 inhibitors, carbenoxolone (CBO) is one of the most commonly used, which is a semisynthetic derivative of 18[beta]-glycyrrethinic acid a type of triterpene found in several plants (Classen-Houben et al.