Of great concern is the over-use of carbapenems
in hospitals for treating Gram-negative bacterial infections, which is contributing to the increasing emergence of carbapenem
The use of carbapenems
and piperacillin/tazobactam - seen as "lastresort" antibiotics - rose by 36% and 55% respectively, from 2010 to 2014.
The use of "last-resort" drugs carbapenems
and piperacillin/tazobactam rocketed by 36% and 55% respectively.
3,5,16] Colistin is usually combined with sulbactam, cephalosporins, carbapenems
, piperacillin-tazobactam, monobactams, aminoglycosides, fluoroquinolones, rifampin, tetracyclines and tigecycline.
isolates that did not meet definitions 2 and 5, a total of 12 (86%) were susceptible to all carbapenems
tested except ertapenem.
NYSE MKT: SYN), this week presented initial data that support the Company's development of a platform of therapeutics designed to protect the microbiome from carbapenems
, a class of beta-lactam antibiotics.
Like most carbapenemases, KPCs are enzymes which inactivate all beta-lactam antibiotics, including carbapenems
, penicillins, cephalosporins and monobactams.
are a group of antibiotics that had broad-spectrum activity when first introduced.
The infections have been linked to medical scopes believed to have been contaminated with bacteria that can resist carbapenems
, potent antibiotics that are supposed to be used only in gravely ill patients or those infected by resistant bacteria.
Limited treatment options for these multi-resistant isolates have forced the use of carbapenems
, particularly for serious infections, often resulting in the emergence of carbapenemase producing isolates--at an alarming rate in some countries (11).
This new study, co-authored by Dr Ben Evans of Anglia Ruskin University and funded by King Abdulaziz City for Science and Technology and King Faisal University, has shown for the first time that diabetic patients with an Acinetobacter baumannii infection are more likely than non-diabetic patients to contract strains of the bacterium that are resistant to carbapenems
, a group of last-line-of-defence antibiotics.
Recently, some of these bacteria have become resistant to even last-resort antibiotics such as carbapenems
, according to the Centers for Disease Control and Prevention.