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capsid |
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capsid /cap·sid/ (kap´sid) the shell of protein that protects the nucleic acid of a virus; it is composed of structural units, or capsomers.
Capsid The outer protein coat of a virus. Mentioned in: Noroviruses capsid [kap′sid] Etymology: L, capsa, box the layer of protein enveloping the genome of a virion. A capsid is composed of structural units called capsomeres. Its symmetry may be cubic or helical. capsid the shell of protein that protects the nucleic acid of a virus; it is composed of individual morphological units called capsomers. For icosahedral viruses, there are two kinds of capsomers called pentamers, which occupy the 12 corner positions of the icosahedral shell, and hexamers, which occupy the face and edges. The number of hexamers varies between different viruses. The capsomers of helical viruses are composed of a single polypeptide and are also called protomers. All viruses of animals, except for poxviruses which have a complex structure, are minimally composed of a nucleocapsid which is the capsid surrounding the nucleic acid. In addition some viruses have an envelope surrounding the nucleocapsid. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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A heminested PCR targeting the major capsid protein gene was performed (3), amplicons were sequenced (SeqWright DNA Technology Services, Houston, TX, USA), and a GenBank BLAST search (www. Gelbart were struck by the fact that experiments dating back to the 1960s showed that viral capsids with icosahedral symmetry will form spontaneously in a solution of capsid proteins, given the right conditions of temperature, pH, and salinity. The difference is that protease inhibitors target the protease enzyme, while PA-457 uses other mechanisms (in technical language, it blocks release of the capsid protein). |
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