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capreomycin |
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capreomycin /cap·reo·my·cin/ (kap?re-o-mi´sin) a polypeptide antibiotic produced by Streptomyces capreolus, which is active against human strains of Mycobacterium tuberculosis ; used as the disulfate salt.
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Susceptibility to first-line (streptomycin, isoniazid, rifampin, and ethambutol) and second-line (kana-mycin, ethionamide, capreomycin, cycloserine, p-aminosalicylic acid, and ofloxacin) drugs was determined by the proportion method on Middlebrook 7H10 agar. The anti-TB medications included in the screening were isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, ethionamide, kanamycin, cycloserine, capreomycin, paraaminosalicylic acid (PAS), and drugs containing any combination of these medications. Returned to West Africa after 4 months DOT C INH, rifampin, PZA, and Sputum culture and smear ethambutol by DOT for 6 negative, chest months radiograph improved D Capreomycin, ofloxacin, Sputum smear and culture PAS, clofazamine, and converted to negative, cycloserine for 2 y by symptoms resolved. |
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