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cantharidin |
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cantharidin (kan·tharˑ·  ·dn),n bitter-tasting, crystalline substance that is the active principle of cantharides and is also found in the bodies of some species of beetles; causes blistering on skin and is lethal to some animals that consume dead bodies of beetles in hay. cantharidin the most active principle of cantharides with similar activity. Preparations containing cantharidin are used topically as a vesicant to remove warts and were popular at one time as rubefacients for horses. |
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We also investigated the AhR-dependent activities of cantharidin and emodin (in herbal extracts) in Ah-responsive MCF-7 human breast cells, HepG2 human liver cancer cells, and mouse Hepa-1 cells transiently or stably transfected with plasmids expressing a luciferase reporter gene linked to multiple copies of a consensus dioxin-responsive element. One subject reported 5 prior treatments, including injection, cantharidin in acetone, and laser. Attending physicians noted that the symptoms resembled those seen in men who had overindulged in a drug called cantharidin -- popularly known as Spanish fly -- which is extracted from a particular beetle for its purported value as an aphrodisiac. |
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cantharidin
